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Arhgdia Gene Detail
Summary
  • Symbol
    Arhgdia
  • Name
    Rho GDP dissociation inhibitor alpha
  • Synonyms
    5330430M07Rik, Rho-GDI, Rho GDIalpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:2178103
    NCBI Gene: 192662
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:120468930-120472450 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 84.29 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    4 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2178103
 protein coding gene Chr11:120468925-120472450 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019511
 protein coding gene Chr11:125049410-125052930 (-)
A/J MGP_AJ_G0019479
 protein coding gene Chr11:119487078-119490598 (-)
AKR/J MGP_AKRJ_G0019449
 protein coding gene Chr11:123082291-123085811 (-)
BALB/cJ MGP_BALBcJ_G0019454
 protein coding gene Chr11:119842839-119846359 (-)
C3H/HeJ MGP_C3HHeJ_G0019260
 protein coding gene Chr11:123418200-123421784 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019902
 protein coding gene Chr11:128838270-128841790 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017528
 protein coding gene Chr11:116478675-116482211 (-)
CAST/EiJ MGP_CASTEiJ_G0018814
 protein coding gene Chr11:124917228-124921467 (-)
CBA/J MGP_CBAJ_G0019231
 protein coding gene Chr11:133874532-133878052 (-)
DBA/2J MGP_DBA2J_G0019343
 protein coding gene Chr11:118856205-118859725 (-)
FVB/NJ MGP_FVBNJ_G0019335
 protein coding gene Chr11:118568076-118572064 (-)
LP/J MGP_LPJ_G0019415
 protein coding gene Chr11:125353738-125357126 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019368
 protein coding gene Chr11:132711044-132714577 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019942
 protein coding gene Chr11:123770815-123774335 (-)
PWK/PhJ MGP_PWKPhJ_G0018580
 protein coding gene Chr11:120292075-120296497 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018372
 protein coding gene Chr11:123533832-123537353 (-)
WSB/EiJ MGP_WSBEiJ_G0018866
 protein coding gene Chr11:123760219-123763739 (-)



Homology
more
  • Human Ortholog
    ARHGDIA, Rho GDP dissociation inhibitor alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGDIA, Rho GDP dissociation inhibitor alpha
  • Synonyms
    GDIA1, HEL-S-47e, NPHS8, RHOGDI, RHOGDI-1
  • Links
    NCBI Gene ID: 396
    neXtProt AC: NX_P52565
    UniProt: P52565

  • Chr Location
    17q25.3; chr17:81867721-81871378 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Arhgdia mouse models; 1 with human ARHGDIA associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    39 phenotypes from 1 allele in 1 genetic background
    25 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation develop nephrotic syndrome, including renal tubule dilation and degeneration, leading to premature death from renal failure. Male mice are sterile and female mice exhibit reduced fertility from postimplantation defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    771
  • Tissues
    29
  • cDNA Data
    15
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025132 Ensembl Gene Model | MGI Sequence Detail 3521 C57BL/6J ±  kb
    transcript ENSMUST00000106197 Ensembl | MGI Sequence Detail 1867 Not Applicable  
    polypeptide ENSMUSP00000101803 Ensembl | MGI Sequence Detail 204 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 15
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1924426
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 13
      Phenotypes 13
    • Earliest
      J:36812 Zalcman G, et al., RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG. J Biol Chem. 1996 29;271(48):30366-74
    • Latest
      J:320610 Auguste D, et al., Disease-causing mutations of RhoGDIalpha induce Rac1 hyperactivation in podocytes. Small GTPases. 2016 Apr 2;7(2):107-21
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory