Acsm1 MGI Mouse Gene Detail - MGI:2152200 - acyl-CoA synthetase medium-chain family member 1

Symbol

Acsm1
Name

acyl-CoA synthetase medium-chain family member 1
Synonyms

Bucs1, Macs

Feature Type

protein coding gene
IDs

MGI:2152200
NCBI Gene: 117147
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr7:119217035-119261738 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 64.02 cM, cytoband F3
Mapping Data

1 experiment

SNPs within 2kb

1297 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2152200	protein coding gene	Chr7:119206249-119261738 (+)
129S1/SvImJ	ENSMUSG00200021305	protein coding gene	Chr7:105723948-105779452 (+)
A/J	ENSMUSG00195032288	protein coding gene	Chr7:110243123-110299529 (+)
AKR/J	ENSMUSG00220021718	protein coding gene	Chr7:103684706-103740193 (+)
BALB/cJ	ENSMUSG00180027201	protein coding gene	Chr7:106906325-106962741 (+)
C3H/HeJ	ENSMUSG00175021224	protein coding gene	Chr7:107619882-107676285 (+)
C57BL/6NJ	ENSMUSG00215012086	protein coding gene	Chr7:106879116-106934605 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030380	protein coding gene	Chr7:121774582-121834662 (+)
CAST/EiJ	ENSTCUG00005043966	protein coding gene	Chr7:110189035-110246443 (+)
CBA/J	ENSMUSG00210022740	protein coding gene	Chr7:107342404-107398804 (+)
DBA/2J	ENSMUSG00185043391	protein coding gene	Chr7:111693397-111749802 (+)
FVB/NJ	ENSMUSG00205016351	protein coding gene	Chr7:107341350-107396848 (+)
JF1/MsJ	ENSUMUG00000042808	protein coding gene	Chr7:116756292-116817892 (+)
LP/J	ENSMUSG00230031381	protein coding gene	Chr7:117810873-117866365 (+)
NOD/ShiLtJ	ENSMUSG00190026889	protein coding gene	Chr7:107555301-107610791 (+)
NZO/HlLtJ	ENSMUSG00225039629	protein coding gene	Chr7:116049921-116106322 (+)
PWK/PhJ	ENSLUMG00010009539	protein coding gene	Chr7:105887278-105943682 (+)
SPRET/EiJ	ENSMSPG00010009028	protein coding gene	Chr7:107097092-107153279 (+)
WSB/EiJ	ENSIUOG00005010792	protein coding gene	Chr7:108223353-108279026 (+)

Human Ortholog

ACSM1, acyl-CoA synthetase medium chain family member 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ACSM1, acyl-CoA synthetase medium chain family member 1
Synonyms

BUCS1, MACS1
Links

HGNC:18049

NCBI Gene ID: 116285

UniProt: Q08AH1
Chr Location

16p12.3; chr16:20623233-20698890 (-) GRCh38

MGI Vertebrate Homology

Acsm1 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: ACSM1
Gene Tree

Acsm1

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

3
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

32 strains or lines available

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All GO Annotations

38
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

759
Tissues

131
cDNA Data

44
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

42
RefSeq

6
UniProt

3
CCDS

CCDS21783.1

Ensembl

ENSMUSG00000033533 (Evidence)
NCBI Gene

117147

			Length	Strain/Species	Flank
genomic	117147	NCBI Gene Model \| MGI Sequence Detail	44704	C57BL/6J	± kb
transcript	NM_054094	RefSeq \| MGI Sequence Detail	2052	C57BL/6
polypeptide	Q91VA0	UniProt \| EBI \| MGI Sequence Detail	573	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000003664 acyl-coenzyme A synthetase ACSM1, mitochondrial

(term hierarchy)
EC

6.2.1.2, 6.2.1.25
InterPro Domains

IPR020845 AMP-binding, conserved site

IPR025110 AMP-binding enzyme, C-terminal domain

IPR045851 AMP-binding enzyme domain superfamily

IPR000873 AMP-dependent synthetase/ligase domain

IPR042099 ANL, N-terminal domain

IPR051087 Mitochondrial Acyl-CoA Synthetase Medium-Chain
GlyGen

Q91VA0 1 site, 1 O-linked glycan (1 site)

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All nucleic 44

cDNA 44

Microarray probesets 3

Summaries

All 45

Developmental Gene Expression 5

Gene Ontology 12

Phenotypes 8
Earliest

J:71662 Fujino T, et al., Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product. J Biol Chem. 2001 Sep 21;276(38):35961-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Acsm1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68748	Chr7:119217016-119217025 (+)	-14 bp
Tssr68749	Chr7:119217027-119217042 (+)	0 bp
Tssr68750	Chr7:119239520-119239528 (+)	22,489 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24