About   Help   FAQ
Tecpr2 Gene Detail
Summary
  • Symbol
    Tecpr2
  • Name
    tectonin beta-propeller repeat containing 2
  • Synonyms
    4930573I19Rik, mKIAA0297
  • Feature Type
    protein coding gene
  • IDs
    MGI:2144865
    NCBI Gene: 104859
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:110855698-110938828 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 60.86 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    421 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2144865
 protein coding gene Chr12:110855681-110938828 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020124
 protein coding gene Chr12:113235352-113322038 (+)
A/J MGP_AJ_G0020080
 protein coding gene Chr12:108885688-108978227 (+)
AKR/J MGP_AKRJ_G0020055
 protein coding gene Chr12:112018489-112101486 (+)
BALB/cJ MGP_BALBcJ_G0020065
 protein coding gene Chr12:109310141-109393371 (+)
C3H/HeJ MGP_C3HHeJ_G0019867
 protein coding gene Chr12:112478150-112566559 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020510
 protein coding gene Chr12:116761113-116849211 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018123
 protein coding gene Chr12:105336628-105423569 (+)
CAST/EiJ MGP_CASTEiJ_G0019408
 protein coding gene Chr12:107361515-107452623 (+)
CBA/J MGP_CBAJ_G0019834
 protein coding gene Chr12:121242950-121333927 (+)
DBA/2J MGP_DBA2J_G0019951
 protein coding gene Chr12:108380539-108464414 (+)
FVB/NJ MGP_FVBNJ_G0019936
 protein coding gene Chr12:107169435-107253353 (+)
LP/J MGP_LPJ_G0020026
 protein coding gene Chr12:113060342-113143334 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019974
 protein coding gene Chr12:124363138-124450564 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020539
 protein coding gene Chr12:111503107-111587998 (+)
PWK/PhJ MGP_PWKPhJ_G0019169
 protein coding gene Chr12:103000377-103089344 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018972
 protein coding gene Chr12:105684459-105769313 (+)
WSB/EiJ MGP_WSBEiJ_G0019467
 protein coding gene Chr12:112443558-112533634 (+)



Homology
more
  • Human Ortholog
    TECPR2, tectonin beta-propeller repeat containing 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TECPR2, tectonin beta-propeller repeat containing 2
  • Synonyms
    HSAN9, KIAA0329, SPG49
  • Links
    NCBI Gene ID: 9895
    neXtProt AC: NX_O15040
    UniProt: O15040

  • Chr Location
    14q32.31; chr14:102362941-102502477 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TECPR2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit neurodegeneration, abnormal gait, increased mechanical nociceptive threshold, decreased thermal nociceptive threshold, and impaired autophagy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    1
  • cDNA Data
    52
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021275 Ensembl Gene Model | MGI Sequence Detail 83131 C57BL/6J ±  kb
    transcript ENSMUST00000165978 Ensembl | MGI Sequence Detail 7778 Not Applicable  
    polypeptide ENSMUSP00000127949 Ensembl | MGI Sequence Detail 1423 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR006624 Beta-propeller repeat TECPR
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 52
      cDNA 52

      Microarray probesets 3
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 1
      Gene Ontology 2
      Phenotypes 8
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:304963 Tamim-Yecheskel BC, et al., A tecpr2 knockout mouse exhibits age-dependent neuroaxonal dystrophy associated with autophagosome accumulation. Autophagy. 2020;Dec 10:1-14
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory