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Kmo Gene Detail
Summary
  • Symbol
    Kmo
  • Name
    kynurenine 3-monooxygenase
  • Synonyms
    kynurenine 3-hydroxylase
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138151
    NCBI Gene: 98256
  • Alliance
    genome feature page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:175459759-175488419 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 81.60 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1175 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2138151
 protein coding gene Chr1:175447947-175489682 (+)
129S1/SvImJ ENSMUSG00200022003
 protein coding gene Chr1:173205921-173247488 (+)
A/J ENSMUSG00195042093
 protein coding gene Chr1:172620045-172661684 (+)
AKR/J ENSMUSG00220030158
 protein coding gene Chr1:172204570-172246297 (+)
BALB/cJ ENSMUSG00180042948
 protein coding gene Chr1:172856840-172898397 (+)
C3H/HeJ ENSMUSG00175039843
 protein coding gene Chr1:173033007-173074566 (+)
C57BL/6NJ ENSMUSG00215042756
 protein coding gene Chr1:172408739-172450476 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014944
 protein coding gene Chr1:165710723-165753442 (+)
CAST/EiJ ENSTCUG00005046362
 protein coding gene Chr1:170931483-170974176 (+)
CBA/J ENSMUSG00210039355
 protein coding gene Chr1:172666001-172707734 (+)
DBA/2J ENSMUSG00185028435
 protein coding gene Chr1:177278781-177320509 (+)
FVB/NJ ENSMUSG00205027144
 protein coding gene Chr1:171782067-171823811 (+)
JF1/MsJ ENSUMUG00000016074
 protein coding gene Chr1:176131563-176173729 (+)
LP/J ENSMUSG00230031507
 protein coding gene Chr1:176872085-176913644 (+)
NOD/ShiLtJ ENSMUSG00190029958
 protein coding gene Chr1:172707574-172749129 (+)
NZO/HlLtJ ENSMUSG00225004043
 protein coding gene Chr1:180465196-180495220 (+)
PWK/PhJ ENSLUMG00010032252
 protein coding gene Chr1:171419906-171461488 (+)
SPRET/EiJ ENSMSPG00010031536
 protein coding gene Chr1:175048530-175090358 (+)
WSB/EiJ ENSIUOG00005036478
 protein coding gene Chr1:171778236-171819965 (+)



Homology
more
  • Human Ortholog
    KMO, kynurenine 3-monooxygenase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KMO, kynurenine 3-monooxygenase
  • Synonyms
    dJ317G22.1
  • Links
    NCBI Gene ID: 8564
    UniProt: O15229

  • Chr Location
    1q43; chr1:241532134-241595642 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele lack kynurenine 3-monooxygenase activity and altered levels of several tryptophan metabolites. Mice homozygous for another null allele exhibit increased LPS-induced depressive behaviors and altered kynurenine metabolism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    64
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    701
  • Tissues
    98
  • cDNA Data
    10
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 98256 NCBI Gene Model | MGI Sequence Detail 28661 C57BL/6J ±  kb
    transcript NM_133809 RefSeq | MGI Sequence Detail 2512 FVB/N  
    polypeptide Q91WN4 UniProt | EBI | MGI Sequence Detail 479 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 3
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 3
      Gene Ontology 16
      Phenotypes 31
    • Earliest
      J:86816 Mootha VK, et al., Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell. 2003 Nov 26;115(5):629-40
    • Latest
      J:386607 Hasegawa M, et al., Chronic stress induces behavioural changes through increased kynurenic acid by downregulation of kynurenine-3-monooxygenase with microglial decline. Br J Pharmacol. 2025 Apr;182(7):1466-1486
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory