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Baiap2 Gene Detail
Summary
  • Symbol
    Baiap2
  • Name
    brain-specific angiogenesis inhibitor 1-associated protein 2
  • Synonyms
    IRSp53
  • Feature Type
    protein coding gene
  • IDs
    MGI:2137336
    NCBI Gene: 108100
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:119833762-119897608 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 83.96 cM, cytoband E2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    111 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2137336
 protein coding gene Chr11:119833589-119897608 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019487
 protein coding gene Chr11:124370038-124437100 (+)
A/J MGP_AJ_G0019455
 protein coding gene Chr11:118844647-118909182 (+)
AKR/J MGP_AKRJ_G0019425
 protein coding gene Chr11:122424086-122488610 (+)
BALB/cJ MGP_BALBcJ_G0019430
 protein coding gene Chr11:119200448-119264787 (+)
C3H/HeJ MGP_C3HHeJ_G0019236
 protein coding gene Chr11:122744068-122809334 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019879
 protein coding gene Chr11:128135758-128204106 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017504
 protein coding gene Chr11:115846383-115912099 (+)
CAST/EiJ MGP_CASTEiJ_G0018790
 protein coding gene Chr11:124219027-124285878 (+)
CBA/J MGP_CBAJ_G0019207
 protein coding gene Chr11:133147966-133220040 (+)
DBA/2J MGP_DBA2J_G0019319
 protein coding gene Chr11:118211178-118274994 (+)
FVB/NJ MGP_FVBNJ_G0019311
 protein coding gene Chr11:117895989-117963515 (+)
LP/J MGP_LPJ_G0019391
 protein coding gene Chr11:124682127-124745976 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019344
 protein coding gene Chr11:132022146-132088114 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019918
 protein coding gene Chr11:123103094-123169854 (+)
PWK/PhJ MGP_PWKPhJ_G0018556
 protein coding gene Chr11:119636737-119701428 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018348
 protein coding gene Chr11:122870149-122934046 (+)
WSB/EiJ MGP_WSBEiJ_G0018842
 protein coding gene Chr11:123096922-123165030 (+)



Homology
more
  • Human Ortholog
    BAIAP2, BAR/IMD domain containing adaptor protein 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BAIAP2, BAR/IMD domain containing adaptor protein 2
  • Synonyms
    BAP2, FLAF3, IRSP53, WAML
  • Links
    NCBI Gene ID: 10458
    neXtProt AC: NX_Q9UQB8
    UniProt: Q9UQB8

  • Chr Location
    17q25.3; chr17:81035122-81117434 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human BAIAP2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    40 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a knock-out allele show mid to late gestation lethality, developmental delay, oligodactyly, subcutaneous edema, and severely impaired cardiac and placental development. Adult homozygotes fail to regulate synaptic plasticity and exhibit hippocampus-associated learning deficits.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    68
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    890
  • Tissues
    87
  • cDNA Data
    113
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 108100 NCBI Gene Model | MGI Sequence Detail 63847 C57BL/6J ±  kb
    transcript NM_130862 RefSeq | MGI Sequence Detail 3186 C57BL/6  
    polypeptide Q8BKX1 UniProt | EBI | MGI Sequence Detail 535 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 116
      cDNA 113
      Primer pair 2
      Other 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2144701
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 11
      Gene Ontology 18
      Phenotypes 20
    • Earliest
      J:62164 Fujiwara T, et al., Rho small G-protein-dependent binding of mDia to an Src homology 3 domain-containing IRSp53/BAIAP2. Biochem Biophys Res Commun. 2000 May 19;271(3):626-9
    • Latest
      J:334410 Feng Z, et al., IRSp53 promotes postsynaptic density formation and actin filament bundling. J Cell Biol. 2022 Aug 1;221(8)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory