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Sorcs2 Gene Detail
Summary
  • Symbol
    Sorcs2
  • Name
    sortilin-related VPS10 domain containing receptor 2
  • Synonyms
    mKIAA1329, VPS10 domain receptor protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932289
    NCBI Gene: 81840
  • Alliance
    genome feature page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:36174524-36555483 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 19.14 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    10804 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1932289
 protein coding gene Chr5:36174524-36555541 (-)
129S1/SvImJ ENSMUSG00200031255
 protein coding gene Chr5:31643916-32025158 (-)
A/J ENSMUSG00195029131
 protein coding gene Chr5:31117804-31498160 (-)
AKR/J ENSMUSG00220002092
 protein coding gene Chr5:31144571-31524738 (-)
BALB/cJ ENSMUSG00180020799
 protein coding gene Chr5:30920667-31301011 (-)
C3H/HeJ ENSMUSG00175019211
 protein coding gene Chr5:32900172-33285258 (-)
C57BL/6NJ ENSMUSG00215005049
 protein coding gene Chr5:31641151-32022399 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027154
 protein coding gene Chr5:30959640-31331637 (-)
CAST/EiJ ENSTCUG00005023825
 protein coding gene Chr5:31125124-31499313 (-)
CBA/J ENSMUSG00210004169
 protein coding gene Chr5:31868976-32249292 (-)
DBA/2J ENSMUSG00185016344
 protein coding gene Chr5:33736566-34116931 (-)
FVB/NJ ENSMUSG00205025687
 protein coding gene Chr5:30616871-31000984 (-)
JF1/MsJ ENSUMUG00000042717
 protein coding gene Chr5:38339259-38714866 (-)
LP/J ENSMUSG00230043143
 protein coding gene Chr5:38347512-38728738 (-)
NOD/ShiLtJ ENSMUSG00190002767
 protein coding gene Chr5:30897837-31300355 (-)
NZO/HlLtJ ENSMUSG00225015673
 protein coding gene Chr5:43550840-43932069 (-)
PWK/PhJ ENSLUMG00010022638
 protein coding gene Chr5:31030046-31404474 (-)
SPRET/EiJ ENSMSPG00010032302
 protein coding gene Chr5:32242210-32622541 (-)
WSB/EiJ ENSIUOG00005016467
 protein coding gene Chr5:33825460-34215340 (-)



Homology
more
  • Human Ortholog
    SORCS2, sortilin related VPS10 domain containing receptor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SORCS2, sortilin related VPS10 domain containing receptor 2
  • Links
    NCBI Gene ID: 57537
    UniProt: Q96PQ0

  • Chr Location
    4p16.1; chr4:7192538-7742827 (+)  GRCh38
Human Diseases
less
  • References
    11 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 1 allele in 1 genetic background
    981 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to reduced dopamine levels and dopamine metabolism, dopaminergic hyperinnervation of the frontal cortex, hyperactivity, abnormal behavioral response to amphetamine, and decreased induction of Schwann cell apoptosis following sciatic nerve injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    785
  • Tissues
    108
  • cDNA Data
    56
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029093 Ensembl Gene Model | MGI Sequence Detail 380960 C57BL/6J ±  kb
    transcript ENSMUST00000037370 Ensembl | MGI Sequence Detail 5707 Not Applicable  
    polypeptide ENSMUSP00000041828 Ensembl | MGI Sequence Detail 1159 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 61
      cDNA 59
      Primer pair 2
      Antibodies 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2141349
    References
    more
    • Summaries
      All 1014
      Developmental Gene Expression 12
      Diseases 11
      Gene Ontology 10
      Phenotypes 981
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:390820 Xia J, et al., Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro-Inflammatory Endothelial Cells. Adv Sci (Weinh). 2026 Jun 17;:e10448
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory