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Tnxb Gene Detail
Summary
  • Symbol
    Tnxb
  • Name
    tenascin XB
  • Synonyms
    TN-MHC, Tnx
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932137
    NCBI Gene: 81877
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34879431-34938789 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.24 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1932137
 protein coding gene Chr17:34879427-34938789 (+)
129S1/SvImJ ENSMUSG00200049556
 protein coding gene Chr17:30582602-30641961 (+)
A/J ENSMUSG00195036050
 protein coding gene Chr17:31483807-31542158 (+)
AKR/J ENSMUSG00220040437
 protein coding gene Chr17:30511442-30570854 (+)
BALB/cJ ENSMUSG00180035417
 protein coding gene Chr17:30853679-30912033 (+)
C3H/HeJ ENSMUSG00175028595
 protein coding gene Chr17:30397546-30456957 (+)
C57BL/6NJ ENSMUSG00215046856
 protein coding gene Chr17:30422768-30482142 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021472
 protein coding gene Chr17:31448006-31517888 (+)
CAST/EiJ ENSTCUG00005040608
 protein coding gene Chr17:31441920-31500438 (+)
CBA/J ENSMUSG00210047428
 protein coding gene Chr17:30219652-30279058 (+)
DBA/2J ENSMUSG00185045575
 protein coding gene Chr17:32872951-32931298 (+)
FVB/NJ ENSMUSG00205040506
 protein coding gene Chr17:30741184-30800506 (+)
JF1/MsJ ENSUMUG00000050979
 protein coding gene Chr17:32125601-32183969 (+)
LP/J ENSMUSG00230054576
 protein coding gene Chr17:33980878-34040240 (+)
NOD/ShiLtJ ENSMUSG00190044177
 protein coding gene Chr17:30343589-30401944 (+)
NZO/HlLtJ ENSMUSG00225053420
 protein coding gene Chr17:35994376-36053748 (+)
PWK/PhJ ENSLUMG00010046662
 protein coding gene Chr17:29951291-30010633 (+)
SPRET/EiJ ENSMSPG00010043015
 protein coding gene Chr17:31143024-31203519 (+)
WSB/EiJ ENSIUOG00005050002
 protein coding gene Chr17:31070100-31129472 (+)



Homology
more
  • Human Ortholog
    TNXA, tenascin XA (pseudogene)
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNXA, tenascin XA (pseudogene)
  • Synonyms
    D6S103E, HXBL, TNX, XA
  • Links
    NCBI Gene ID: 7146
    UniProt: Q16473

  • Chr Location
    6p21.33; chr6:32008420-32013023 (-)  GRCh38
  • Human Ortholog
    TNXB, tenascin XB
  • Synonyms
    EDS3, EDSCLL, EDSCLL1, HXBL, TENX, TN-X, TNX, TNXB1, TNXB2, TNXBS, VUR8, XB, XBS
  • Links
    NCBI Gene ID: 7148
    UniProt: P22105

  • Chr Location
    6p21.33-p21.32; chr6:32041153-32115334 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human TNXB associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice have stretchy skin, similar to patients with human Ehlers-Danlos syndrome.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    683
  • Tissues
    61
  • cDNA Data
    23
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033327 Ensembl Gene Model | MGI Sequence Detail 59359 C57BL/6J ±  kb
    transcript ENSMUST00000238967 Ensembl | MGI Sequence Detail 13300 Not Applicable  
    polypeptide ENSMUSP00000158977 Ensembl | MGI Sequence Detail 4356 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • InterPro Domains
      IPR000742 EGF-like domain
      IPR050991 Extracellular Matrix Regulatory Proteins
      IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
      IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
      IPR020837 Fibrinogen, conserved site
      IPR036056 Fibrinogen-like, C-terminal
      IPR003961 Fibronectin type III
      IPR036116 Fibronectin type III superfamily
      IPR013783 Immunoglobulin-like fold
      IPR041161 Tenascin, EGF-like domain
    • GlyGen
      A0A5F8MPH8 16 sites, 4 N-linked glycans (4 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 1
      cDNA 23
      Primer pair 2
      Other 3
      Antibodies 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-18691, MGI:101866
    References
    more
    • Summaries
      All 81
      Developmental Gene Expression 13
      Gene Ontology 15
      Phenotypes 26
    • Earliest
      J:36890 Saga Y, et al., Mice develop normally without tenascin. Genes Dev. 1992 Oct;6(10):1821-31
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory