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Smoc2 Gene Detail
Summary
  • Symbol
    Smoc2
  • Name
    SPARC related modular calcium binding 2
  • Synonyms
    1700056C05Rik, 5430426J21Rik, Smoc2l
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929881
    NCBI Gene: 64074
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:14499768-14625052 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 8.95 cM, cytoband A2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4136 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929881
 protein coding gene Chr17:14499768-14625052 (+)
129S1/SvImJ ENSMUSG00200037238
 protein coding gene Chr17:10143757-10268989 (+)
A/J ENSMUSG00195037351
 protein coding gene Chr17:10936712-11061977 (+)
AKR/J ENSMUSG00220022084
 protein coding gene Chr17:10584130-10709392 (+)
BALB/cJ ENSMUSG00180016451
 protein coding gene Chr17:10075427-10200678 (+)
C3H/HeJ ENSMUSG00175038196
 protein coding gene Chr17:10070348-10195637 (+)
C57BL/6NJ ENSMUSG00215040309
 protein coding gene Chr17:10236911-10362234 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021085
 protein coding gene Chr17:9960145-10083181 (+)
CAST/EiJ ENSTCUG00005022633
 protein coding gene Chr17:10585536-10714764 (+)
CBA/J ENSMUSG00210033177
 protein coding gene Chr17:9851319-9976628 (+)
DBA/2J ENSMUSG00185038422
 protein coding gene Chr17:11709947-11835196 (+)
FVB/NJ ENSMUSG00205027822
 protein coding gene Chr17:10556020-10681361 (+)
JF1/MsJ ENSUMUG00000025060
 protein coding gene Chr17:11418968-11544521 (+)
LP/J ENSMUSG00230026396
 protein coding gene Chr17:13138913-13264143 (+)
NOD/ShiLtJ ENSMUSG00190025680
 protein coding gene Chr17:10310055-10440370 (+)
NZO/HlLtJ ENSMUSG00225046031
 protein coding gene Chr17:15061132-15186355 (+)
PWK/PhJ ENSLUMG00010019179
 protein coding gene Chr17:10084061-10209323 (+)
SPRET/EiJ ENSMSPG00010031481
 protein coding gene Chr17:11333773-11454854 (+)
WSB/EiJ ENSIUOG00005039618
 protein coding gene Chr17:10922993-11048250 (+)



Homology
more
  • Human Ortholog
    SMOC2, SPARC related modular calcium binding 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SMOC2, SPARC related modular calcium binding 2
  • Synonyms
    bA270C4A.1, bA37D8.1, dJ421D16.1, DTDP1, DTDP1A, MST117, MSTP117, MSTP140, SMAP2
  • Links
    NCBI Gene ID: 64094
    UniProt: Q9H3U7

  • Chr Location
    6q27; chr6:168440656-168673445 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 3 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one KO allele exhibit protection from induced kidney fibrosis and reduced interstitial myofibroblast accumulation. Another KO allele leads to shortening and widening of the skull.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    955
  • Tissues
    226
  • cDNA Data
    67
  • Literature Summary
    42
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 64074 NCBI Gene Model | MGI Sequence Detail 125285 C57BL/6J ±  kb
    transcript NM_022315 RefSeq | MGI Sequence Detail 2832 ZRU/MplStud  
    polypeptide Q8CD91 UniProt | EBI | MGI Sequence Detail 447 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 76
      cDNA 69
      Primer pair 5
      Other 2
      Antibodies 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1918668, MGI:1920709, MGI:1935165
    References
    more
    • Summaries
      All 95
      Developmental Gene Expression 42
      Gene Ontology 9
      Phenotypes 18
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:381485 Gao P, et al., Matricellular protein SMOC2 safeguards tubular integrity in acute kidney injury via integrin beta3-dependent inhibition of CCND1-CDK4/6 axis. Mol Biomed. 2026 Feb 10;7(1):11
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory