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Pex3 Gene Detail
Summary
  • Symbol
    Pex3
  • Name
    peroxisomal biogenesis factor 3
  • Synonyms
    1700014F15Rik, 2810027F19Rik, 2900010N04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929646
    NCBI Gene: 56535
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:13399586-13428886 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 4.89 cM, cytoband A
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    871 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929646
 protein coding gene Chr10:13399586-13428886 (-)
129S1/SvImJ ENSMUSG00200010166
 protein coding gene Chr10:10407772-10437057 (-)
A/J ENSMUSG00195006596
 protein coding gene Chr10:10333968-10363275 (-)
AKR/J ENSMUSG00220010081
 protein coding gene Chr10:10435922-10465232 (-)
BALB/cJ ENSMUSG00180014747
 protein coding gene Chr10:10490896-10520203 (-)
C3H/HeJ ENSMUSG00175019021
 protein coding gene Chr10:10487144-10516451 (-)
C57BL/6NJ ENSMUSG00215003525
 protein coding gene Chr10:10350880-10380180 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015126
 protein coding gene Chr10:9802815-9832115 (-)
CAST/EiJ ENSTCUG00005029733
 protein coding gene Chr10:10350916-10380270 (-)
CBA/J ENSMUSG00210015423
 protein coding gene Chr10:10436877-10466183 (-)
DBA/2J ENSMUSG00185006601
 protein coding gene Chr10:10483751-10512987 (-)
FVB/NJ ENSMUSG00205017196
 protein coding gene Chr10:10529226-10558505 (-)
JF1/MsJ ENSUMUG00000011531
 protein coding gene Chr10:10526194-10555424 (-)
LP/J ENSMUSG00230014878
 protein coding gene Chr10:12090212-12119518 (-)
NOD/ShiLtJ ENSMUSG00190010545
 protein coding gene Chr10:10463399-10492696 (-)
NZO/HlLtJ ENSMUSG00225015776
 protein coding gene Chr10:16594148-16623427 (-)
PWK/PhJ ENSLUMG00010014938
 protein coding gene Chr10:10274141-10303372 (-)
SPRET/EiJ ENSMSPG00010010421
 protein coding gene Chr10:10675279-10704716 (-)
WSB/EiJ ENSIUOG00005020850
 protein coding gene Chr10:10066423-10095931 (-)



Homology
more
  • Human Ortholog
    PEX3, peroxisomal biogenesis factor 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PEX3, peroxisomal biogenesis factor 3
  • Synonyms
    PBD10A, PBD10B, TRG18
  • Links
    NCBI Gene ID: 8504
    UniProt: P56589

  • Chr Location
    6q24.2; chr6:143450805-143490616 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PEX3 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit abnormal sebaceous gland, hair follicle bulge, and cornea morphology. An increase in B and T cell numbers and mean platelet volume, and vertebral transformation are also seen.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    604
  • Tissues
    6
  • cDNA Data
    54
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56535 NCBI Gene Model | MGI Sequence Detail 29301 C57BL/6J ±  kb
    transcript NM_019961 RefSeq | MGI Sequence Detail 2303 C57BL/6  
    polypeptide Q9QXY9 UniProt | EBI | MGI Sequence Detail 372 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 57
      Genomic 1
      cDNA 55
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1914452, MGI:1914509, MGI:1922773
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 2
      Gene Ontology 10
      Phenotypes 13
    • Earliest
      J:66341 Muntau AC, et al., Genomic organization, expression analysis, and chromosomal localization of the mouse PEX3 gene encoding a peroxisomal assembly protein. Biol Chem. 2000 Apr;381(4):337-42
    • Latest
      J:366336 Sun JT, et al., PEX3 promotes regenerative repair after myocardial injury in mice through facilitating plasma membrane localization of ITGB3. Commun Biol. 2024 Jul 1;7(1):795
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory