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Dstn Gene Detail
Summary
  • Symbol
    Dstn
  • Name
    destrin
  • Synonyms
    2610043P17Rik, ADF, corn1, sid23p
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929270
    NCBI Gene: 56431
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:143757251-143785244 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 70.89 cM, cytoband H1
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    272 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929270
 protein coding gene Chr2:143757240-143785244 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026578
 protein coding gene Chr2:147964797-147994245 (+)
A/J MGP_AJ_G0026542
 protein coding gene Chr2:141989804-142017630 (+)
AKR/J MGP_AKRJ_G0026516
 protein coding gene Chr2:146064037-146093668 (+)
BALB/cJ MGP_BALBcJ_G0026554
 protein coding gene Chr2:142422972-142465139 (+)
C3H/HeJ MGP_C3HHeJ_G0026297
 protein coding gene Chr2:146606282-146638740 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026999
 protein coding gene Chr2:152425664-152455411 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024376
 protein coding gene Chr2:136181602-136209361 (+)
CAST/EiJ MGP_CASTEiJ_G0025758
 protein coding gene Chr2:146930682-146962284 (+)
CBA/J MGP_CBAJ_G0026277
 protein coding gene Chr2:157966469-158000243 (+)
DBA/2J MGP_DBA2J_G0026411
 protein coding gene Chr2:141282581-141310183 (+)
FVB/NJ MGP_FVBNJ_G0026375
 protein coding gene Chr2:139868261-139896992 (+)
LP/J MGP_LPJ_G0026515
 protein coding gene Chr2:148139778-148168284 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026395
 protein coding gene Chr2:162201114-162229721 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027054
 protein coding gene Chr2:146067664-146097162 (+)
PWK/PhJ MGP_PWKPhJ_G0025495
 protein coding gene Chr2:140936100-140966527 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025295
 protein coding gene Chr2:145111650-145138973 (+)
WSB/EiJ MGP_WSBEiJ_G0025831
 protein coding gene Chr2:147078051-147107962 (+)



Homology
more
  • Human Ortholog
    DSTN, destrin, actin depolymerizing factor
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DSTN, destrin, actin depolymerizing factor
  • Synonyms
    ACTDP, ADF, bA462D18.2, HEL32
  • Links
    NCBI Gene ID: 11034
    neXtProt AC: NX_P60981
    UniProt: P60981

  • Chr Location
    20p12.1; chr20:17570075-17609919 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 4 alleles in 7 genetic backgrounds
    7 phenotypes from multigenic genotypes
    1 images
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice carrying mutations at this locus develop irregular thickening of the corneal epithelium.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1034
  • Tissues
    75
  • cDNA Data
    13
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56431 NCBI Gene Model | MGI Sequence Detail 27994 C57BL/6J ±  kb
    transcript NM_019771 RefSeq | MGI Sequence Detail 1918 Not Specified  
    polypeptide Q9R0P5 UniProt | EBI | MGI Sequence Detail 165 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 14
      Primer pair 1
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-33921, MGI:106229, MGI:1917157, MGI:2139214
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 12
      Gene Ontology 5
      Phenotypes 42
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:315709 McGrath J, et al., Actin at stereocilia tips is regulated by mechanotransduction and ADF/cofilin. Curr Biol. 2021 Mar 22;31(6):1141-1153.e7
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory