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Trpv6 Gene Detail
Summary
  • Symbol
    Trpv6
  • Name
    transient receptor potential cation channel, subfamily V, member 6
  • Synonyms
    Cac, CAT, CaT1, Ecac2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927259
    NCBI Gene: 64177
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:41597558-41613339 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 19.79 cM, cytoband B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    312 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927259
 protein coding gene Chr6:41597553-41613339 (-)
129S1/SvImJ ENSMUSG00200042966
 protein coding gene Chr6:38655464-38671243 (-)
A/J ENSMUSG00195034484
 protein coding gene Chr6:38625175-38640958 (-)
AKR/J ENSMUSG00220006421
 protein coding gene Chr6:38225960-38241737 (-)
BALB/cJ ENSMUSG00180043067
 protein coding gene Chr6:38753545-38769332 (-)
C3H/HeJ ENSMUSG00175037591
 protein coding gene Chr6:38580666-38596453 (-)
C57BL/6NJ ENSMUSG00215042194
 protein coding gene Chr6:38679334-38695121 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028275
 protein coding gene Chr6:36162837-36178536 (-)
CAST/EiJ ENSTCUG00005025616
 protein coding gene Chr6:38085226-38100892 (-)
CBA/J ENSMUSG00210048221
 protein coding gene Chr6:38632425-38648212 (-)
DBA/2J ENSMUSG00185039626
 protein coding gene Chr6:38734915-38750708 (-)
FVB/NJ ENSMUSG00205047681
 protein coding gene Chr6:38535074-38550826 (-)
JF1/MsJ ENSUMUG00000023445
 protein coding gene Chr6:38278276-38293987 (-)
LP/J ENSMUSG00230039868
 protein coding gene Chr6:39658587-39674370 (-)
NOD/ShiLtJ ENSMUSG00190048135
 protein coding gene Chr6:38524358-38540140 (-)
NZO/HlLtJ ENSMUSG00225016343
 protein coding gene Chr6:41641228-41657011 (-)
PWK/PhJ ENSLUMG00010040406
 protein coding gene Chr6:38110492-38126194 (-)
SPRET/EiJ ENSMSPG00010026616
 protein coding gene Chr6:38834814-38850434 (-)
WSB/EiJ ENSIUOG00005027167
 protein coding gene Chr6:38792032-38807813 (-)



Homology
more
  • Human Ortholog
    TRPV6, transient receptor potential cation channel subfamily V member 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRPV6, transient receptor potential cation channel subfamily V member 6
  • Synonyms
    ABP/ZF, CAT1, CATL, ECAC2, HRPTTN, HSA277909, LP6728, ZFAB
  • Links
    NCBI Gene ID: 55503
    UniProt: Q9H1D0

  • Chr Location
    7q34; chr7:142871208-142885745 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TRPV6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-in allele exhibit impaired sperm motility and decreased fertilization by sperm.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    753
  • Tissues
    54
  • cDNA Data
    13
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029868 Ensembl Gene Model | MGI Sequence Detail 15782 C57BL/6J ±  kb
    transcript ENSMUST00000031902 Ensembl | MGI Sequence Detail 2923 Not Applicable  
    polypeptide ENSMUSP00000031902 Ensembl | MGI Sequence Detail 767 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000000777 transient receptor potential cation channel subfamily V member 6
      (term hierarchy)
    • PDB
      2RFA
    • InterPro Domains
      IPR002110 Ankyrin repeat
      IPR036770 Ankyrin repeat-containing domain superfamily
      IPR005821 Ion transport domain
      IPR024862 Transient receptor potential cation channel subfamily V
      IPR008344 Transient receptor potential cation channel subfamily V member 5/6
      IPR008345 Transient receptor potential cation channel subfamily V member 6
    • GlyGen
      Q91WD2 2 sites
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 14
      Primer pair 6
      Antibodies 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 100
      Developmental Gene Expression 13
      Gene Ontology 16
      Phenotypes 26
    • Earliest
      J:65748 Peng JB, et al., Human calcium transport protein CaT1. Biochem Biophys Res Commun. 2000 Nov 19;278(2):326-32
    • Latest
      J:375918 Masamune A, et al., TRPV6-related pancreatitis: natural history and the impact of the pancreas-specific deletion on pancreatitis in mice. J Gastroenterol. 2025 Nov 17;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory