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Cnot10 Gene Detail
Summary
  • Symbol
    Cnot10
  • Name
    CCR4-NOT transcription complex, subunit 10
  • Synonyms
    2600001P13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926143
    NCBI Gene: 78893
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:114414946-114469252 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 64.72 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1656 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926143
 protein coding gene Chr9:114414942-114469289 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035391
 protein coding gene Chr9:117022859-117085810 (-)
A/J MGP_AJ_G0035371
 protein coding gene Chr9:112743395-112799580 (-)
AKR/J MGP_AKRJ_G0035304
 protein coding gene Chr9:115614761-115669935 (-)
BALB/cJ MGP_BALBcJ_G0035367
 protein coding gene Chr9:112542927-112598564 (-)
C3H/HeJ MGP_C3HHeJ_G0035075
 protein coding gene Chr9:116117280-116171422 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035890
 protein coding gene Chr9:120234106-120290575 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032773
 protein coding gene Chr9:110045704-110100017 (-)
CAST/EiJ MGP_CASTEiJ_G0034380
 protein coding gene Chr9:115962985-116021429 (-)
CBA/J MGP_CBAJ_G0035042
 protein coding gene Chr9:124732065-124796360 (-)
DBA/2J MGP_DBA2J_G0035201
 protein coding gene Chr9:112222764-112277730 (-)
FVB/NJ MGP_FVBNJ_G0035148
 protein coding gene Chr9:111034437-111096376 (-)
LP/J MGP_LPJ_G0035280
 protein coding gene Chr9:117374011-117427558 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035189
 protein coding gene Chr9:125961665-126036901 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035909
 protein coding gene Chr9:115984537-116045303 (-)
PWK/PhJ MGP_PWKPhJ_G0034086
 protein coding gene Chr9:112521466-112580748 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033920
 protein coding gene Chr9:116031183-116093043 (-)
WSB/EiJ MGP_WSBEiJ_G0034500
 protein coding gene Chr9:115862663-115921430 (-)



Homology
more
  • Human Ortholog
    CNOT10, CCR4-NOT transcription complex subunit 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CNOT10, CCR4-NOT transcription complex subunit 10
  • Links
    NCBI Gene ID: 25904
    neXtProt AC: NX_Q9H9A5
    UniProt: Q9H9A5

  • Chr Location
    3p22.3; chr3:32685145-32773875 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    8
  • GO References
    5
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    744
  • Tissues
    30
  • cDNA Data
    18
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000056167 Ensembl Gene Model | MGI Sequence Detail 54307 C57BL/6J ±  kb
transcript ENSMUST00000070117 Ensembl | MGI Sequence Detail 2853 Not Applicable  
polypeptide ENSMUSP00000064840 Ensembl | MGI Sequence Detail 744 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000005649 CCR4-NOT transcription complex subunit 10
    (term hierarchy)
  • InterPro Domains
    IPR039740 CCR4-NOT transcription complex subunit 10
    IPR011990 Tetratricopeptide-like helical domain superfamily
    IPR019734 Tetratricopeptide repeat
  • GlyGen
    Q8BH15 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)
Molecular
Reagents
less
  • All nucleic 18
    cDNA 18

    Microarray probesets 3
References
more
  • Summaries
    All 35
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/22/2024
MGI 6.24 		The Jackson Laboratory