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Abcb5 Gene Detail
Summary
  • Symbol
    Abcb5
  • Name
    ATP-binding cassette, sub-family B member 5
  • Synonyms
    9230106F14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924956
    NCBI Gene: 77706
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:118831559-118930156 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 63.48 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2399 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924956
 protein coding gene Chr12:118831221-118930169 (-)
129S1/SvImJ ENSMUSG00200026548
 protein coding gene Chr12:111202922-111302016 (-)
A/J ENSMUSG00195010068
 protein coding gene Chr12:113878930-113975777 (-)
AKR/J ENSMUSG00220033270
 protein coding gene Chr12:111003276-111102387 (-)
BALB/cJ ENSMUSG00180006423
 protein coding gene Chr12:113705689-113804984 (-)
C3H/HeJ ENSMUSG00175002180
 protein coding gene Chr12:114775458-114874556 (-)
C57BL/6NJ ENSMUSG00215004775
 protein coding gene Chr12:111703064-111802151 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018187
 protein coding gene Chr12:113719648-113814358 (-)
CAST/EiJ ENSTCUG00005039400
 protein coding gene Chr12:111699026-111798368 (-)
CBA/J ENSMUSG00210012286
 protein coding gene Chr12:112058048-112157136 (-)
DBA/2J ENSMUSG00185014368
 protein coding gene Chr12:114556063-114655168 (-)
FVB/NJ ENSMUSG00205005031
 protein coding gene Chr12:113074488-113173568 (-)
JF1/MsJ ENSUMUG00000017137
 protein coding gene Chr12:118825606-118923850 (-)
LP/J ENSMUSG00230044253
 protein coding gene Chr12:120927601-121026657 (-)
NOD/ShiLtJ ENSMUSG00190025233
 protein coding gene Chr12:110575389-110674490 (-)
NZO/HlLtJ ENSMUSG00225041948
 protein coding gene Chr12:122752562-122856121 (-)
PWK/PhJ ENSLUMG00010004096
 protein coding gene Chr12:111921360-112020195 (-)
SPRET/EiJ ENSMSPG00010011769
 protein coding gene Chr12:114730828-114830089 (-)
WSB/EiJ ENSIUOG00005035811
 protein coding gene Chr12:111388811-111487882 (-)



Homology
more
  • Human Ortholog
    ABCB5, ATP binding cassette subfamily B member 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ABCB5, ATP binding cassette subfamily B member 5
  • Synonyms
    ABCB5alpha, ABCB5beta, EST422562
  • Links
    NCBI Gene ID: 340273
    UniProt: Q2M3G0

  • Chr Location
    7p21.1; chr7:20615667-20777038 (+)  GRCh38
Human Diseases
less
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    70 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display limbal stem cell abnormalities, impaired cornea development and repair, and retinal abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    692
  • Tissues
    95
  • cDNA Data
    3
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000072791 Ensembl Gene Model | MGI Sequence Detail 98598 C57BL/6J ±  kb
    transcript ENSMUST00000035515 Ensembl | MGI Sequence Detail 3876 Not Applicable  
    polypeptide ENSMUSP00000046177 Ensembl | MGI Sequence Detail 1255 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 4
      cDNA 3
      Primer pair 1
      Antibodies 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 98
      Developmental Gene Expression 2
      Diseases 4
      Gene Ontology 10
      Phenotypes 70
    • Earliest
      J:42265 Huang TT, et al., Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32
    • Latest
      J:385727 Harada K, et al., Preventing Differentiation Towards Primitive Macrophages in Stem Cells With Down Syndrome. Immunology. 2026 Mar;177(3):596-612
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory