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Zfyve26 Gene Detail
Summary
  • Symbol
    Zfyve26
  • Name
    zinc finger, FYVE domain containing 26
  • Synonyms
    9330197E15Rik, A630028O16Rik, LOC380767
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924767
    NCBI Gene: 211978
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:79279120-79343078 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 35.51 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1982 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924767
 protein coding gene Chr12:79279120-79343102 (-)
129S1/SvImJ ENSMUSG00200046664
 protein coding gene Chr12:71244590-71308505 (-)
A/J ENSMUSG00195031918
 protein coding gene Chr12:73941586-74005491 (-)
AKR/J ENSMUSG00220046434
 protein coding gene Chr12:71719662-71783576 (-)
BALB/cJ ENSMUSG00180017252
 protein coding gene Chr12:72912339-72976241 (-)
C3H/HeJ ENSMUSG00175041374
 protein coding gene Chr12:76073975-76137897 (-)
C57BL/6NJ ENSMUSG00215045124
 protein coding gene Chr12:72278576-72342559 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017891
 protein coding gene Chr12:73676732-73746150 (-)
CAST/EiJ ENSTCUG00005024961
 protein coding gene Chr12:72209787-72273490 (-)
CBA/J ENSMUSG00210038879
 protein coding gene Chr12:72488312-72552167 (-)
DBA/2J ENSMUSG00185040400
 protein coding gene Chr12:74348959-74412827 (-)
FVB/NJ ENSMUSG00205016529
 protein coding gene Chr12:72090357-72154101 (-)
JF1/MsJ ENSUMUG00000008349
 protein coding gene Chr12:78332919-78398056 (-)
LP/J ENSMUSG00230040624
 protein coding gene Chr12:81362771-81426709 (-)
NOD/ShiLtJ ENSMUSG00190040266
 protein coding gene Chr12:71546995-71610723 (-)
NZO/HlLtJ ENSMUSG00225049820
 protein coding gene Chr12:83417692-83481558 (-)
PWK/PhJ ENSLUMG00010028193
 protein coding gene Chr12:72357726-72422491 (-)
SPRET/EiJ ENSMSPG00010016492
 protein coding gene Chr12:74176816-74241549 (-)
WSB/EiJ ENSIUOG00005041251
 protein coding gene Chr12:72167744-72232036 (-)



Homology
more
  • Human Ortholog
    ZFYVE26, zinc finger FYVE-type containing 26
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZFYVE26, zinc finger FYVE-type containing 26
  • Synonyms
    FYVE-CENT, SPG15
  • Links
    NCBI Gene ID: 23503
    UniProt: Q68DK2

  • Chr Location
    14q24.1; chr14:67727374-67816590 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Zfyve26 mouse models; 1 with human ZFYVE26 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 3 alleles in 3 genetic backgrounds
    5 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display a late-onset spastic gait disorder with cerebellar ataxia, axon degeneration, and progressive loss of cortical motoneurons and Purkinje cells preceded by accumulation of autofluorescent, electron-dense, membrane-enclosed material in lysosomal structures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    603
  • Tissues
    3
  • cDNA Data
    73
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000066440 Ensembl Gene Model | MGI Sequence Detail 63959 C57BL/6J ±  kb
    transcript ENSMUST00000021547 Ensembl | MGI Sequence Detail 9391 Not Applicable  
    polypeptide ENSMUSP00000021547 Ensembl | MGI Sequence Detail 2529 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 74
      cDNA 74

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2685739
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 9
      Phenotypes 15
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory