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Glrx5 Gene Detail
Summary
  • Symbol
    Glrx5
  • Name
    glutaredoxin 5
  • Synonyms
    2310004O13Rik, 2900070E19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920296
    NCBI Gene: 73046
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:104998877-105007170 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 55.04 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    387 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920296
 protein coding gene Chr12:104998877-105009165 (+)
129S1/SvImJ ENSMUSG00200023555
 protein coding gene Chr12:96765702-96775920 (+)
A/J ENSMUSG00195017291
 protein coding gene Chr12:99327380-99337598 (+)
AKR/J ENSMUSG00220033597
 protein coding gene Chr12:97205099-97215319 (+)
BALB/cJ ENSMUSG00180032094
 protein coding gene Chr12:98511006-98521225 (+)
C3H/HeJ ENSMUSG00175032273
 protein coding gene Chr12:101139527-101149747 (+)
C57BL/6NJ ENSMUSG00215040499
 protein coding gene Chr12:97801600-97811817 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018082
 protein coding gene Chr12:99517177-99525234 (+)
CAST/EiJ ENSTCUG00005017886
 protein coding gene Chr12:97262909-97272940 (+)
CBA/J ENSMUSG00210014481
 protein coding gene Chr12:98206802-98217022 (+)
DBA/2J ENSMUSG00185043408
 protein coding gene Chr12:99972969-99983187 (+)
FVB/NJ ENSMUSG00205011768
 protein coding gene Chr12:97196632-97206852 (+)
JF1/MsJ ENSUMUG00000007307
 protein coding gene Chr12:104718489-104728624 (+)
LP/J ENSMUSG00230027452
 protein coding gene Chr12:107031035-107041253 (+)
NOD/ShiLtJ ENSMUSG00190022687
 protein coding gene Chr12:87998038-88008256 (-)
NZO/HlLtJ ENSMUSG00225036934
 protein coding gene Chr12:108766188-108776406 (+)
PWK/PhJ ENSLUMG00010012798
 protein coding gene Chr12:98165742-98176201 (+)
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005007767
 protein coding gene Chr12:97212063-97222246 (+)



Homology
more
  • Human Ortholog
    GLRX5, glutaredoxin 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GLRX5, glutaredoxin 5
  • Synonyms
    C14orf87, FLB4739, GRX5, PR01238, PRO1238, PRSA, SIDBA3, SPAHGC
  • Links
    NCBI Gene ID: 51218
    UniProt: Q86SX6

  • Chr Location
    14q32.13; chr14:95533503-95544724 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GLRX5 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    4
  • Targeted
    2
  • Genomic Mutations
    1 involving Glrx5
  • Find Mice (IMSR)
    5 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    44
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 73046 NCBI Gene Model | MGI Sequence Detail 8294 C57BL/6J ±  kb
transcript NM_028419 RefSeq | MGI Sequence Detail 1002 C57BL/6  
polypeptide Q80Y14 UniProt | EBI | MGI Sequence Detail 152 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 46
    cDNA 46

    Microarray probesets 2
Other
Accession IDs
less
MGI:1916773, MGI:2144971
References
more
  • Summaries
    All 40
    Gene Ontology 9
    Phenotypes 7
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:245433 Petry SF, et al., Differential expression of islet glutaredoxin 1 and 5 with high reactive oxygen species production in a mouse model of diabesity. PLoS One. 2017;12(5):e0176267
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory