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Marchf1 Gene Detail
Summary
  • Symbol
    Marchf1
  • Name
    membrane associated ring-CH-type finger 1
  • Synonyms
    2900024D24Rik, March1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920175
    NCBI Gene: 72925
  • Alliance
    genome feature page
  • Transcription Start Sites
    30 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:66070552-66924289 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 33.06 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    25480 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920175
 protein coding gene Chr8:66070552-66925761 (+)
129S1/SvImJ ENSMUSG00200031277
 protein coding gene Chr8:60909634-61767371 (+)
A/J ENSMUSG00195014183
 protein coding gene Chr8:61279341-62171110 (+)
AKR/J ENSMUSG00220022194
 protein coding gene Chr8:61095559-61956400 (+)
BALB/cJ ENSMUSG00180019858
 protein coding gene Chr8:60884503-61743462 (+)
C3H/HeJ ENSMUSG00175018856
 protein coding gene Chr8:61109546-61968491 (+)
C57BL/6NJ ENSMUSG00215018347
 protein coding gene Chr8:60894689-61750766 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031092
 protein coding gene Chr8:58073376-58855067 (+)
CAST/EiJ ENSTCUG00005030757
 protein coding gene Chr8:60670301-61528405 (+)
CBA/J ENSMUSG00210027350
 protein coding gene Chr8:60990378-61847430 (+)
DBA/2J ENSMUSG00185022156
 protein coding gene Chr8:67043358-67900503 (+)
FVB/NJ ENSMUSG00205010882
 protein coding gene Chr8:60434378-61285839 (+)
JF1/MsJ ENSUMUG00000007560
 protein coding gene Chr8:69335017-70172170 (+)
LP/J ENSMUSG00230033440
 protein coding gene Chr8:70701954-71560843 (+)
NOD/ShiLtJ ENSMUSG00190025777
 protein coding gene Chr8:60880506-61782150 (+)
NZO/HlLtJ ENSMUSG00225047607
 protein coding gene Chr8:74112578-74978412 (+)
PWK/PhJ ENSLUMG00010026914
 protein coding gene Chr8:60781202-61622218 (+)
SPRET/EiJ ENSMSPG00010032759
 protein coding gene Chr8:62317162-62915842 (+)
WSB/EiJ ENSIUOG00005024511
 protein coding gene Chr8:61737116-62610298 (+)



Homology
more
  • Human Ortholog
    MARCHF1, membrane associated ring-CH-type finger 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MARCHF1, membrane associated ring-CH-type finger 1
  • Synonyms
    MARCH1, MARCH-I, RNF171
  • Links
    NCBI Gene ID: 55016
    UniProt: Q8TCQ1

  • Chr Location
    4q32.2-q32.3; chr4:163524298-164384050 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal dendritic cell morphology and physiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    722
  • Tissues
    15
  • cDNA Data
    23
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036469 Ensembl Gene Model | MGI Sequence Detail 853738 C57BL/6J ±  kb
transcript ENSMUST00000110256 Ensembl | MGI Sequence Detail 3288 Not Applicable  
polypeptide ENSMUSP00000105885 Ensembl | MGI Sequence Detail 540 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 23
    cDNA 23

    Microarray probesets 4
Other
Accession IDs
less
MGI:2142827, MGI:6368844
References
more
  • Summaries
    All 67
    Developmental Gene Expression 3
    Gene Ontology 11
    Phenotypes 27
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:343688 Kozono Y, et al., Ubiquitination of Major Histocompatibility Complex II Changes Its Immunological Recognition Structure. Int J Mol Sci. 2023 Dec 3;24(23)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory