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Zbtb46 Gene Detail
Summary
  • Symbol
    Zbtb46
  • Name
    zinc finger and BTB domain containing 46
  • Synonyms
    2610019F01Rik, 4933406L05Rik, Btbd4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919397
    NCBI Gene: 72147
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:181029555-181101219 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 103.63 cM, cytoband H4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1583 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919397
 protein coding gene Chr2:181012105-181134776 (-)
129S1/SvImJ ENSMUSG00200002446
 protein coding gene Chr2:177052110-177123733 (-)
A/J ENSMUSG00195001093
 protein coding gene Chr2:177284110-177355529 (-)
AKR/J ENSMUSG00220000073
 protein coding gene Chr2:174962741-175034176 (-)
BALB/cJ ENSMUSG00180000630
 protein coding gene Chr2:175091398-175164875 (-)
C3H/HeJ ENSMUSG00175004374
 protein coding gene Chr2:176244679-176316092 (-)
C57BL/6NJ ENSMUSG00215002496
 protein coding gene Chr2:175191612-175263286 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024808
 protein coding gene Chr2:170921799-170996449 (-)
CAST/EiJ ENSTCUG00005000797
 protein coding gene Chr2:174542743-174614601 (-)
CBA/J ENSMUSG00210001243
 protein coding gene Chr2:175569961-175641527 (-)
DBA/2J ENSMUSG00185020186
 protein coding gene Chr2:176804120-176875536 (-)
FVB/NJ ENSMUSG00205002339
 protein coding gene Chr2:175621729-175693368 (-)
JF1/MsJ ENSUMUG00000025946
 protein coding gene Chr2:177997052-178068191 (-)
LP/J ENSMUSG00230022967
 protein coding gene Chr2:178703044-178774660 (-)
NOD/ShiLtJ ENSMUSG00190016007
 protein coding gene Chr2:175111526-175183161 (-)
NZO/HlLtJ ENSMUSG00225006607
 protein coding gene Chr2:186785382-186856751 (-)
PWK/PhJ ENSLUMG00010000283
 protein coding gene Chr2:175416681-175488046 (-)
SPRET/EiJ ENSMSPG00010004058
 protein coding gene Chr2:177891595-177962816 (-)
WSB/EiJ ENSIUOG00005000137
 protein coding gene Chr2:175130445-175201896 (-)



Homology
more
  • Human Ortholog
    ZBTB46, zinc finger and BTB domain containing 46
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZBTB46, zinc finger and BTB domain containing 46
  • Synonyms
    BTBD4, BZEL, dJ583P15.7, dJ583P15.8, RINZF, ZNF340
  • Links
    NCBI Gene ID: 140685
    UniProt: Q86UZ6

  • Chr Location
    20q13.33; chr20:63743668-63833895 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 4 alleles in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    1 images
    180 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit repressed altered myeloid potential in dendritic cells. Mice homozygous for a different knock-out allele exhibit partial activation of classical dendritic cells in the steady state.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    647
  • Tissues
    32
  • cDNA Data
    32
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027583 Ensembl Gene Model | MGI Sequence Detail 71665 C57BL/6J ±  kb
    transcript ENSMUST00000029106 Ensembl | MGI Sequence Detail 5309 Not Applicable  
    polypeptide ENSMUSP00000029106 Ensembl | MGI Sequence Detail 600 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      cDNA 34
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1918297
    References
    more
    • Summaries
      All 220
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 180
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:391375 Yeung KKM, et al., 4-1BBL on monocyte lineage cells rather than on classical dendritic cells drives CD8(+) T cell accumulation in the respiratory tract and protects from severe respiratory influenza infection. Mucosal Immunol. 2026 Jul 1;:100374
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory