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Sulf2 Gene Detail
Summary
  • Symbol
    Sulf2
  • Name
    sulfatase 2
  • Synonyms
    2010004N24Rik, mKIAA1247
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919293
    NCBI Gene: 72043
  • Alliance
    genome feature page
  • Transcription Start Sites
    28 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:165915819-165997603 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 86.31 cM, cytoband H3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2681 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919293
 protein coding gene Chr2:165915009-165997603 (-)
129S1/SvImJ ENSMUSG00200040418
 protein coding gene Chr2:162792991-162875529 (-)
A/J ENSMUSG00195023164
 protein coding gene Chr2:163134668-163217386 (-)
AKR/J ENSMUSG00220030726
 protein coding gene Chr2:162466687-162549073 (-)
BALB/cJ ENSMUSG00180031958
 protein coding gene Chr2:162588314-162671028 (-)
C3H/HeJ ENSMUSG00175041000
 protein coding gene Chr2:163333936-163416314 (-)
C57BL/6NJ ENSMUSG00215015104
 protein coding gene Chr2:162789682-162872273 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024695
 protein coding gene Chr2:158020759-158103110 (-)
CAST/EiJ ENSTCUG00005044472
 protein coding gene Chr2:161693379-161775643 (-)
CBA/J ENSMUSG00210033928
 protein coding gene Chr2:163268783-163351493 (-)
DBA/2J ENSMUSG00185025054
 protein coding gene Chr2:163001090-163083469 (-)
FVB/NJ ENSMUSG00205016988
 protein coding gene Chr2:162022083-162104462 (-)
JF1/MsJ ENSUMUG00000025969
 protein coding gene Chr2:162643516-162726101 (-)
LP/J ENSMUSG00230011085
 protein coding gene Chr2:164553918-164636455 (-)
NOD/ShiLtJ ENSMUSG00190030896
 protein coding gene Chr2:162673746-162756448 (-)
NZO/HlLtJ ENSMUSG00225050079
 protein coding gene Chr2:172563323-172645696 (-)
PWK/PhJ ENSLUMG00010045606
 protein coding gene Chr2:162546308-162628845 (-)
SPRET/EiJ ENSMSPG00010026120
 protein coding gene Chr2:165295034-165376878 (-)
WSB/EiJ ENSIUOG00005023155
 protein coding gene Chr2:162397009-162479657 (-)



Homology
more
  • Human Ortholog
    SULF2, sulfatase 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SULF2, sulfatase 2
  • Synonyms
    HSULF-2
  • Links
    NCBI Gene ID: 55959
    UniProt: Q8IWU5

  • Chr Location
    20q13.12; chr20:47656197-47786835 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 7 alleles in 9 genetic backgrounds
    53 phenotypes from multigenic genotypes
    3 images
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous disruption of this gene may lead to a partially penetrant, strain-dependent phenotype of embryonic lethality, reduced postnatal body weight, lung abnormalities, brain malformations, and reduced fertility. Mice homozygous for a hypomorphic gene-trap allele display skeletal defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    70
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    918
  • Tissues
    203
  • cDNA Data
    24
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 72043 NCBI Gene Model | MGI Sequence Detail 81785 C57BL/6J ±  kb
    transcript NM_001355619 RefSeq | MGI Sequence Detail 4001 C57BL/6  
    polypeptide Q8CFG0 UniProt | EBI | MGI Sequence Detail 875 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 27
      Primer pair 9
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2139186
    References
    more
    • Summaries
      All 105
      Developmental Gene Expression 20
      Gene Ontology 18
      Phenotypes 49
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:359868 Whitehead AK, et al., Myeloid Deficiency of Heparan Sulfate 6-O-Endosulfatases Impairs Bone Marrow Hematopoiesis. Matrix Biol. 2024 Oct 3;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory