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Antxr2 Gene Detail
Summary
  • Symbol
    Antxr2
  • Name
    anthrax toxin receptor 2
  • Synonyms
    2310046B19Rik, cI-35, CMG-2, CMG2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919164
    NCBI Gene: 71914
  • Alliance
    genome feature page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:98032547-98178876 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 47.77 cM, cytoband E3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3955 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919164
 protein coding gene Chr5:98030642-98178902 (-)
129S1/SvImJ ENSMUSG00200008298
 protein coding gene Chr5:91761966-91902360 (-)
A/J ENSMUSG00195031159
 protein coding gene Chr5:91322722-91456607 (-)
AKR/J ENSMUSG00220011847
 protein coding gene Chr5:90789445-90930015 (-)
BALB/cJ ENSMUSG00180020706
 protein coding gene Chr5:91476142-91616696 (-)
C3H/HeJ ENSMUSG00175028778
 protein coding gene Chr5:93581560-93715664 (-)
C57BL/6NJ ENSMUSG00215016657
 protein coding gene Chr5:91413617-91561997 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027437
 protein coding gene Chr5:90873074-91005009 (-)
CAST/EiJ ENSTCUG00005036962
 protein coding gene Chr5:90827302-90964450 (-)
CBA/J ENSMUSG00210030929
 protein coding gene Chr5:92340541-92474764 (-)
DBA/2J ENSMUSG00185036171
 protein coding gene Chr5:95256594-95390716 (-)
FVB/NJ ENSMUSG00205019344
 protein coding gene Chr5:91238188-91378742 (-)
JF1/MsJ ENSUMUG00000041696
 protein coding gene Chr5:98221369-98356787 (-)
LP/J ENSMUSG00230023715
 protein coding gene Chr5:99314955-99455333 (-)
NOD/ShiLtJ ENSMUSG00190025927
 protein coding gene Chr5:91249054-91382906 (-)
NZO/HlLtJ ENSMUSG00225012612
 protein coding gene Chr5:107065444-107205996 (-)
PWK/PhJ ENSLUMG00010028163
 protein coding gene Chr5:90346494-90485013 (-)
SPRET/EiJ ENSMSPG00010024417
 protein coding gene Chr5:93211219-93344733 (-)
WSB/EiJ ENSIUOG00005028924
 protein coding gene Chr5:93955511-94096100 (-)



Homology
more
  • Human Ortholog
    ANTXR2, ANTXR cell adhesion molecule 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANTXR2, ANTXR cell adhesion molecule 2
  • Synonyms
    CMG-2, CMG2, HFS, ISH, JHF
  • Links
    NCBI Gene ID: 118429
    UniProt: P58335

  • Chr Location
    4q21.21; chr4:79901146-80125454 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human ANTXR2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 4 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    6 images
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for null mutations display female infertility. Mice homozygous for one allele are highly resistant to Bacillus anthracis or anthrax toxin induced lethality. Young mice homozygous for a second allele display pregnancy-related premature death and failure of parturition.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    605
  • Tissues
    3
  • cDNA Data
    52
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71914 NCBI Gene Model | MGI Sequence Detail 146330 C57BL/6J ±  kb
    transcript NM_133738 RefSeq | MGI Sequence Detail 3806 C57BL/6  
    polypeptide Q6DFX2 UniProt | EBI | MGI Sequence Detail 487 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 55
      cDNA 52
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1930793
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 27
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:373035 Liu J, et al., Anthrax lethal toxin exerts potent metabolic inhibition of the cardiovascular system. mBio. 2024 Dec 11;15(12):e0216024
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory