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Ston2 Gene Detail
Summary
  • Symbol
    Ston2
  • Name
    stonin 2
  • Synonyms
    4933401N24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918272
    NCBI Gene: 108800
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:91599686-91753237 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 45.02 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1041 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918272
 protein coding gene Chr12:91599686-91755161 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020000
 protein coding gene Chr12:92751391-92917138 (-)
A/J MGP_AJ_G0019955
 protein coding gene Chr12:89272735-89425052 (-)
AKR/J MGP_AKRJ_G0019931
 protein coding gene Chr12:91670775-91832202 (-)
BALB/cJ MGP_BALBcJ_G0019941
 protein coding gene Chr12:89558770-89713824 (-)
C3H/HeJ MGP_C3HHeJ_G0019743
 protein coding gene Chr12:92283536-92437261 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020390
 protein coding gene Chr12:95507512-95662202 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018004
 protein coding gene Chr12:86714930-86861906 (-)
CAST/EiJ MGP_CASTEiJ_G0019289
 protein coding gene Chr12:87203931-87362600 (-)
CBA/J MGP_CBAJ_G0019715
 protein coding gene Chr12:99077701-99247393 (-)
DBA/2J MGP_DBA2J_G0019826
 protein coding gene Chr12:88745223-88898539 (-)
FVB/NJ MGP_FVBNJ_G0019815
 protein coding gene Chr12:87618900-87767594 (-)
LP/J MGP_LPJ_G0019902
 protein coding gene Chr12:92553833-92717918 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019856
 protein coding gene Chr12:101851545-102005141 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020419
 protein coding gene Chr12:91285517-91438490 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0019343
 protein coding gene Chr12:92044105-92201146 (-)



Homology
more
  • Human Ortholog
    STON2, stonin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STON2, stonin 2
  • Synonyms
    STN2, STNB, STNB2
  • Links
    NCBI Gene ID: 85439
    neXtProt AC: NX_Q8WXE9
    UniProt: Q8WXE9

  • Chr Location
    14q31.1; chr14:81260652-81436465 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit compromised endocytic synaptic vesicle sorting fidelity, hyperactivity and abnormal response to novel object.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 108800 NCBI Gene Model | MGI Sequence Detail 153552 C57BL/6J ±  kb
    transcript NM_175367 RefSeq | MGI Sequence Detail 9923 C57BL/6  
    polypeptide Q8BZ60 UniProt | EBI | MGI Sequence Detail 895 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2144810, MGI:2145035
    References
    more
    • Summaries
      All 40
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:342492 Bolz S, et al., Synaptotagmin 1-triggered lipid signaling facilitates coupling of exo- and endocytosis. Neuron. 2023 Sep 14;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory