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Rasgef1a Gene Detail
Summary
  • Symbol
    Rasgef1a
  • Name
    RasGEF domain family, member 1A
  • Synonyms
    6330404M18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917977
    NCBI Gene: 70727
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:117988466-118068507 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 55.85 cM, cytoband F1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2455 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917977
 protein coding gene Chr6:117988399-118068507 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031182
 protein coding gene Chr6:120742391-120830497 (+)
A/J MGP_AJ_G0031151
 protein coding gene Chr6:116121567-116202203 (+)
AKR/J MGP_AKRJ_G0031082
 protein coding gene Chr6:119243007-119331929 (+)
BALB/cJ MGP_BALBcJ_G0031162
 protein coding gene Chr6:115898659-115981181 (+)
C3H/HeJ MGP_C3HHeJ_G0030547
 protein coding gene Chr6:64963384-65047778 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031620
 protein coding gene Chr6:123920175-123945283 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028782
 protein coding gene Chr6:113049603-113131730 (+)
CAST/EiJ MGP_CASTEiJ_G0030269
 protein coding gene Chr6:119616936-119710537 (+)
CBA/J MGP_CBAJ_G0030845
 protein coding gene Chr6:128804476-128829561 (+)
DBA/2J MGP_DBA2J_G0031001
 protein coding gene Chr6:115020785-115106288 (+)
FVB/NJ MGP_FVBNJ_G0030953
 protein coding gene Chr6:114152787-114237835 (+)
LP/J MGP_LPJ_G0031080
 protein coding gene Chr6:120770439-120859029 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030987
 protein coding gene Chr6:132909389-132934347 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031649
 protein coding gene Chr6:119331689-119357889 (+)
PWK/PhJ MGP_PWKPhJ_G0029984
 protein coding gene Chr6:114031005-114120834 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029813
 protein coding gene Chr6:117992978-118081229 (+)
WSB/EiJ MGP_WSBEiJ_G0030352
 protein coding gene Chr6:119598578-119625477 (+)



Homology
more
  • Human Ortholog
    RASGEF1A, RasGEF domain family member 1A
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RASGEF1A, RasGEF domain family member 1A
  • Synonyms
    CG4853
  • Links
    NCBI Gene ID: 221002
    UniProt: Q8N9B8

  • Chr Location
    10q11.21; chr10:43194533-43267082 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    727
  • Tissues
    4
  • cDNA Data
    11
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 70727 NCBI Gene Model | MGI Sequence Detail 80042 C57BL/6J ±  kb
transcript NM_001362105 RefSeq | MGI Sequence Detail 3379 C57BL/6  
polypeptide NP_001349032 RefSeq | MGI Sequence Detail 498 C57BL/6  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • InterPro Domains
    IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamily
    IPR023578 Ras guanine nucleotide exchange factor domain superfamily
    IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
    IPR008937 Ras-like guanine nucleotide exchange factor
    IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
Molecular
Reagents
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  • All nucleic 11
    cDNA 11

    Microarray probesets 6
Other
Accession IDs
less
MGI:2141473
References
more
  • Summaries
    All 27
    Developmental Gene Expression 1
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
06/09/2026
MGI 6.24 		The Jackson Laboratory