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Psmd1 Gene Detail
Summary
  • Symbol
    Psmd1
  • Name
    proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
  • Synonyms
    P112, S1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917497
    NCBI Gene: 70247
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:85992341-86067017 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 43.94 cM, cytoband C5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    363 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917497
 protein coding gene Chr1:85992109-86067017 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016241
 protein coding gene Chr1:87301355-87377911 (+)
A/J MGP_AJ_G0016222
 protein coding gene Chr1:84070299-84144503 (+)
AKR/J MGP_AKRJ_G0016183
 protein coding gene Chr1:86501721-86580727 (+)
BALB/cJ MGP_BALBcJ_G0016179
 protein coding gene Chr1:84185087-84260627 (+)
C3H/HeJ MGP_C3HHeJ_G0016007
 protein coding gene Chr1:86756279-86833455 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016635
 protein coding gene Chr1:90625056-90706265 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014357
 protein coding gene Chr1:78560888-78641128 (+)
CAST/EiJ MGP_CASTEiJ_G0015592
 protein coding gene Chr1:85993447-86070853 (+)
CBA/J MGP_CBAJ_G0015983
 protein coding gene Chr1:93444414-93523129 (+)
DBA/2J MGP_DBA2J_G0016086
 protein coding gene Chr1:83379070-83454434 (+)
FVB/NJ MGP_FVBNJ_G0016085
 protein coding gene Chr1:82423637-82498500 (+)
LP/J MGP_LPJ_G0016157
 protein coding gene Chr1:88406934-88484542 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016111
 protein coding gene Chr1:96732515-96808952 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016678
 protein coding gene Chr1:86629251-86706581 (+)
PWK/PhJ MGP_PWKPhJ_G0015379
 protein coding gene Chr1:82659365-82736225 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015159
 protein coding gene Chr1:85607968-85686905 (+)
WSB/EiJ MGP_WSBEiJ_G0015656
 protein coding gene Chr1:86275550-86351990 (+)



Homology
more
  • Human Ortholog
    PSMD1, proteasome 26S subunit, non-ATPase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PSMD1, proteasome 26S subunit, non-ATPase 1
  • Synonyms
    P112, Rpn2, S1
  • Links
    NCBI Gene ID: 5707
    neXtProt AC: NX_Q99460
    UniProt: Q99460

  • Chr Location
    2q37.1; chr2:231056845-231173116 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    751
  • Tissues
    9
  • cDNA Data
    305
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 70247 NCBI Gene Model | MGI Sequence Detail 74677 C57BL/6J ±  kb
transcript NM_027357 RefSeq | MGI Sequence Detail 3256 C57BL/6  
polypeptide Q3TXS7 UniProt | EBI | MGI Sequence Detail 953 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000002176 26S proteasome non-ATPase regulatory subunit 1
    (term hierarchy)
  • InterPro Domains
    IPR048570 26S proteasome non-ATPase regulatory subunit 1/RPN2, N-terminal domain
    IPR016642 26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit
    IPR040623 26S proteasome regulatory subunit RPN2, C-terminal
    IPR011989 Armadillo-like helical
    IPR016024 Armadillo-type fold
    IPR002015 Proteasome/cyclosome repeat
Molecular
Reagents
less
  • All nucleic 305
    cDNA 305

    Microarray probesets 3
References
more
  • Summaries
    All 44
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:338299 Xing L, et al., Autism-linked UBE3A gain-of-function mutation causes interneuron and behavioral phenotypes when inherited maternally or paternally in mice. Cell Rep. 2023 Jun 28;42(7):112706
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory