Klk10 MGI Mouse Gene Detail - MGI:1916790 - kallikrein related-peptidase 10

Symbol

Klk10
Name

kallikrein related-peptidase 10
Synonyms

2300002A13Rik, NES1, PRSSL1

Feature Type

protein coding gene
IDs

MGI:1916790
NCBI Gene: 69540
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr7:43430478-43434834 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 28.26 cM
Mapping Data

3 experiments

SNPs within 2kb

74 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916790	protein coding gene	Chr7:43430459-43434834 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032141	protein coding gene	Chr7:43822679-43827054 (+)
A/J	MGP_AJ_G0032126	protein coding gene	Chr7:42910987-42915362 (+)
AKR/J	MGP_AKRJ_G0032056	protein coding gene	Chr7:44295091-44299466 (+)
BALB/cJ	MGP_BALBcJ_G0032131	protein coding gene	Chr7:43027411-43031917 (+)
C3H/HeJ	MGP_C3HHeJ_G0031847	protein coding gene	Chr7:44800660-44805035 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032615	protein coding gene	Chr7:46030686-46035061 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029638	protein coding gene	Chr7:45044980-45049442 (+)
CAST/EiJ	MGP_CASTEiJ_G0031177	protein coding gene	Chr7:35990744-35995133 (+)
CBA/J	MGP_CBAJ_G0031816	protein coding gene	Chr7:47493536-47498029 (+)
DBA/2J	MGP_DBA2J_G0031965	protein coding gene	Chr7:42717828-42722174 (+)
FVB/NJ	MGP_FVBNJ_G0031926	protein coding gene	Chr7:42428828-42433203 (+)
LP/J	MGP_LPJ_G0032044	protein coding gene	Chr7:44550291-44554666 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031962	protein coding gene	Chr7:46418078-46422453 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032635	protein coding gene	Chr7:43422034-43426409 (+)
PWK/PhJ	MGP_PWKPhJ_G0030898	protein coding gene	Chr7:36167805-36172294 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030737	protein coding gene	Chr7:31452148-31456722 (+)
WSB/EiJ	MGP_WSBEiJ_G0031291	protein coding gene	Chr7:43969986-43974361 (+)

Human Ortholog

KLK10, kallikrein related peptidase 10

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KLK10, kallikrein related peptidase 10
Synonyms

NES1, PRSSL1
Links

HGNC:6358

NCBI Gene ID: 5655

neXtProt AC: NX_O43240

UniProt: O43240
Chr Location

19q13.41; chr19:51012739-51020175 (-) GRCh38

MGI Vertebrate Homology

Klk10 stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: KLK10
Gene Tree

Klk10

Diseases

1 with human KLK10 associations

				Human Disease	Mouse Models
				prostate cancer IDs prostate cancer DOID:10283 DOID:514 ICD10CM:C61 ICD9CM:185 KEGG:05215 MESH:D011471 NCI:C3343 NCI:C7378 OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 ORDO:1331 UMLS_CUI:C0033578 UMLS_CUI:C0376358

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

2
Gene trapped

1
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

1
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

783
Tissues

12
cDNA Data

44
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

31
RefSeq

2
UniProt

2
CCDS

CCDS39936.1

Ensembl

ENSMUSG00000030693 (Evidence)
NCBI Gene

69540

			Length	Strain/Species	Flank
genomic	69540	NCBI Gene Model \| MGI Sequence Detail	4357	C57BL/6J	± kb
transcript	NM_133712	RefSeq \| MGI Sequence Detail	1354	ZRU/MplStud
polypeptide	NP_598473	RefSeq \| MGI Sequence Detail	278	ZRU/MplStud

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UniProt

2 Sequences
InterPro Domains

IPR001314 Peptidase S1A, chymotrypsin family

IPR009003 Peptidase S1, PA clan

IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold

IPR001254 Serine proteases, trypsin domain

IPR018114 Serine proteases, trypsin family, histidine active site

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All nucleic 44

cDNA 44

Microarray probesets 4

Summaries

All 30

Developmental Gene Expression 1

Gene Ontology 1

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:319760 Williams D, et al., Stable flow-induced expression of KLK10 inhibits endothelial inflammation and atherosclerosis. Elife. 2022 Jan 11;11:e72579

TSS for Klk10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr66046	Chr7:43430483-43430502 (+)	15 bp
Tssr66047	Chr7:43432251-43432256 (+)	1,776 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/14/2024 MGI 6.23