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Tmem127 Gene Detail
Summary
  • Symbol
    Tmem127
  • Name
    transmembrane protein 127
  • Synonyms
    2310003P10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916720
    NCBI Gene: 69470
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:127089868-127103028 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 61.87 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    327 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916720
 protein coding gene Chr2:127089828-127103028 (+)
129S1/SvImJ ENSMUSG00200046274
 protein coding gene Chr2:124142799-124156024 (+)
A/J ENSMUSG00195028896
 protein coding gene Chr2:124170984-124184183 (+)
AKR/J ENSMUSG00220039897
 protein coding gene Chr2:123929065-123942290 (+)
BALB/cJ ENSMUSG00180048370
 protein coding gene Chr2:123957881-123971079 (+)
C3H/HeJ ENSMUSG00175040562
 protein coding gene Chr2:124507823-124520989 (+)
C57BL/6NJ ENSMUSG00215022537
 protein coding gene Chr2:124011107-124024308 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024252
 protein coding gene Chr2:120075990-120088973 (+)
CAST/EiJ ENSTCUG00005039145
 protein coding gene Chr2:123304250-123317439 (+)
CBA/J ENSMUSG00210033172
 protein coding gene Chr2:124358287-124371453 (+)
DBA/2J ENSMUSG00185030578
 protein coding gene Chr2:124012293-124025459 (+)
FVB/NJ ENSMUSG00205034824
 protein coding gene Chr2:123165896-123179124 (+)
JF1/MsJ ENSUMUG00000015254
 protein coding gene Chr2:123862558-123875724 (+)
LP/J ENSMUSG00230036636
 protein coding gene Chr2:125778234-125791459 (+)
NOD/ShiLtJ ENSMUSG00190014807
 protein coding gene Chr2:124136030-124149255 (+)
NZO/HlLtJ ENSMUSG00225026692
 protein coding gene Chr2:133684424-133697649 (+)
PWK/PhJ ENSLUMG00010035309
 protein coding gene Chr2:123755868-123769028 (+)
SPRET/EiJ ENSMSPG00010029877
 protein coding gene Chr2:126174886-126188365 (+)
WSB/EiJ ENSIUOG00005036893
 protein coding gene Chr2:123938796-123951990 (+)



Homology
more
  • Human Ortholog
    TMEM127, transmembrane protein 127
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM127, transmembrane protein 127
  • Synonyms
    PPGL8
  • Links
    NCBI Gene ID: 55654
    UniProt: O75204

  • Chr Location
    2q11.2; chr2:96248500-96266047 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TMEM127 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Lysosomal activity and endosomal fusion mediated by Rab5 were affected in mouse embryonic fibroblasts of homozygous null mutants
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    605
  • Tissues
    2
  • cDNA Data
    11
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69470 NCBI Gene Model | MGI Sequence Detail 13161 C57BL/6J ±  kb
    transcript NM_175145 RefSeq | MGI Sequence Detail 4772 ZRU/MplStud  
    polypeptide Q8BGP5 UniProt | EBI | MGI Sequence Detail 238 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 1
      cDNA 11

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2138878, MGI:2138898
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 16
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory