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Trmt1l Gene Detail
Summary
  • Symbol
    Trmt1l
  • Name
    tRNA methyltransferase 1 like
  • Synonyms
    1190005F20Rik, Trm1-like
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916185
    NCBI Gene: 98685
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:151304293-151333912 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 64.12 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1035 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916185
 protein coding gene Chr1:151304293-151333934 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016581
 protein coding gene Chr1:156156630-156189943 (+)
A/J MGP_AJ_G0016563
 protein coding gene Chr1:149848233-149881392 (+)
AKR/J MGP_AKRJ_G0016528
 protein coding gene Chr1:154459677-154494467 (+)
BALB/cJ MGP_BALBcJ_G0016523
 protein coding gene Chr1:150425005-150456027 (+)
C3H/HeJ MGP_C3HHeJ_G0016348
 protein coding gene Chr1:154604193-154635115 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016984
 protein coding gene Chr1:161555652-161591958 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014693
 protein coding gene Chr1:142188472-142219065 (+)
CAST/EiJ MGP_CASTEiJ_G0015927
 protein coding gene Chr1:154033380-154066389 (+)
CBA/J MGP_CBAJ_G0016322
 protein coding gene Chr1:167244979-167278044 (+)
DBA/2J MGP_DBA2J_G0016428
 protein coding gene Chr1:148899002-148929163 (+)
FVB/NJ MGP_FVBNJ_G0016426
 protein coding gene Chr1:147349901-147381410 (+)
LP/J MGP_LPJ_G0016499
 protein coding gene Chr1:157208611-157240997 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016452
 protein coding gene Chr1:174951698-174984783 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017020
 protein coding gene Chr1:154228286-154265654 (+)
PWK/PhJ MGP_PWKPhJ_G0015713
 protein coding gene Chr1:147859274-147890756 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015500
 protein coding gene Chr1:153068859-153097630 (+)
WSB/EiJ MGP_WSBEiJ_G0015990
 protein coding gene Chr1:154330083-154361427 (+)



Homology
more
  • Human Ortholog
    TRMT1L, tRNA methyltransferase 1 like
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRMT1L, tRNA methyltransferase 1 like
  • Synonyms
    bG120K12.3, C1orf25, MST070, MSTP070, TRM1L
  • Links
    NCBI Gene ID: 81627
    neXtProt AC: NX_Q7Z2T5
    UniProt: Q7Z2T5

  • Chr Location
    1q25.3; chr1:185118101-185157537 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    18
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    2
  • Gene trapped
    11
  • Targeted
    3
  • Genomic Mutations
    2 involving Trmt1l
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    73 strains or lines available
Mice homozygous for a gene trapped allele are viable and anatomically normal but display significantly impaired motor coordination and aberrant exploratory behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    898
  • Tissues
    99
  • cDNA Data
    49
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000053286 Ensembl Gene Model | MGI Sequence Detail 29620 C57BL/6J ±  kb
transcript ENSMUST00000065625 Ensembl | MGI Sequence Detail 2749 Not Applicable  
polypeptide ENSMUSP00000068309 Ensembl | MGI Sequence Detail 728 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 55
    cDNA 51
    Primer pair 4

    Microarray probesets 4
Other
Accession IDs
less
MGI:2138580
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 13
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/22/2024
MGI 6.24 		The Jackson Laboratory