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Serpina12 Gene Detail
Summary
  • Symbol
    Serpina12
  • Name
    serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
  • Synonyms
    vaspin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915304
    NCBI Gene: 68054
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:103995028-104010702 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 53.05 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    577 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915304
 protein coding gene Chr12:103995028-104010702 (-)
129S1/SvImJ ENSMUSG00200023263
 protein coding gene Chr12:95726525-95742586 (-)
A/J ENSMUSG00195020041
 protein coding gene Chr12:98321983-98337659 (-)
AKR/J ENSMUSG00220037533
 protein coding gene Chr12:96107309-96123382 (-)
BALB/cJ ENSMUSG00180035319
 protein coding gene Chr12:97441013-97457080 (-)
C3H/HeJ ENSMUSG00175031368
 protein coding gene Chr12:100134705-100150381 (-)
C57BL/6NJ ENSMUSG00215039203
 protein coding gene Chr12:96796632-96812306 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018068
 protein coding gene Chr12:98462735-98480172 (-)
CAST/EiJ ENSTCUG00005018370
 protein coding gene Chr12:96231853-96247627 (-)
CBA/J ENSMUSG00210014238
 protein coding gene Chr12:97132963-97149028 (-)
DBA/2J ENSMUSG00185044490
 protein coding gene Chr12:98899034-98915103 (-)
FVB/NJ ENSMUSG00205015926
 protein coding gene Chr12:96118788-96134476 (-)
JF1/MsJ ENSUMUG00000020481
 protein coding gene Chr12:103689860-103705542 (-)
LP/J ENSMUSG00230029719
 protein coding gene Chr12:105991495-106007563 (-)
NOD/ShiLtJ ENSMUSG00190022026
 protein coding gene Chr12:89063796-89079875 (+)
NZO/HlLtJ ENSMUSG00225036599
 protein coding gene Chr12:107761269-107776943 (-)
PWK/PhJ ENSLUMG00010012234
 protein coding gene Chr12:97134640-97150337 (-)
SPRET/EiJ ENSMSPG00010016425
 protein coding gene Chr12:99520739-99535730 (-)
WSB/EiJ ENSIUOG00005008333
 protein coding gene Chr12:96131679-96147363 (-)



Homology
more
  • Human Ortholog
    SERPINA12, serpin family A member 12
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SERPINA12, serpin family A member 12
  • Synonyms
    OL-64
  • Links
    NCBI Gene ID: 145264
    UniProt: Q8IW75

  • Chr Location
    14q32.13; chr14:94487274-94517844 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice hmomozygous for a knock-out allele exhibit increased body weight, epididymal fat pad weight, liver weight, fat cell size, serum total and small density LDL cholesterol, serum leptin, liver triglyceride and insulin resistance when fed a high fat, high sucrose diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    600
  • Tissues
    2
  • cDNA Data
    12
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68054 NCBI Gene Model | MGI Sequence Detail 15675 C57BL/6J ±  kb
    transcript NM_026535 RefSeq | MGI Sequence Detail 3690 C57BL/6  
    polypeptide Q7TMF5 UniProt | EBI | MGI Sequence Detail 413 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 12
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory