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Dock6 Gene Detail
Summary
  • Symbol
    Dock6
  • Name
    dedicator of cytokinesis 6
  • Synonyms
    2410095B20Rik, 4931431C02Rik, C330023D02Rik, mKIAA1395
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914789
    NCBI Gene: 319899
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:21711476-21764006 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 7.89 cM, cytoband A4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    71 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914789
 protein coding gene Chr9:21711156-21764006 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034463
 protein coding gene Chr9:19062191-19119569 (-)
A/J MGP_AJ_G0034441
 protein coding gene Chr9:18703129-18756509 (-)
AKR/J MGP_AKRJ_G0034368
 protein coding gene Chr9:19066017-19121297 (-)
BALB/cJ MGP_BALBcJ_G0034432
 protein coding gene Chr9:18584845-18638633 (-)
C3H/HeJ MGP_C3HHeJ_G0034144
 protein coding gene Chr9:19364172-19417804 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034953
 protein coding gene Chr9:19811693-19870222 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031883
 protein coding gene Chr9:17806882-17859615 (-)
CAST/EiJ MGP_CASTEiJ_G0033467
 protein coding gene Chr9:19199307-19254751 (-)
CBA/J MGP_CBAJ_G0034117
 protein coding gene Chr9:20589545-20649396 (-)
DBA/2J MGP_DBA2J_G0034276
 protein coding gene Chr9:18670373-18722904 (-)
FVB/NJ MGP_FVBNJ_G0034219
 protein coding gene Chr9:18209719-18268734 (-)
LP/J MGP_LPJ_G0034361
 protein coding gene Chr9:19196094-19254144 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034262
 protein coding gene Chr9:22166743-22221902 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034973
 protein coding gene Chr9:19019057-19075950 (-)
PWK/PhJ MGP_PWKPhJ_G0033172
 protein coding gene Chr9:18669449-18724713 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033007
 protein coding gene Chr9:19065864-19122204 (-)
WSB/EiJ MGP_WSBEiJ_G0033582
 protein coding gene Chr9:18755592-18808179 (-)



Homology
more
  • Human Ortholog
    DOCK6, dedicator of cytokinesis 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DOCK6, dedicator of cytokinesis 6
  • Synonyms
    AOS2, ZIR1
  • Links
    NCBI Gene ID: 57572
    neXtProt AC: NX_Q96HP0
    UniProt: Q96HP0

  • Chr Location
    19p13.2; chr19:11199295-11262524 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DOCK6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    769
  • Tissues
    34
  • cDNA Data
    64
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 319899 NCBI Gene Model | MGI Sequence Detail 52531 C57BL/6J ±  kb
    transcript NM_177030 RefSeq | MGI Sequence Detail 6547 C57BL/6  
    polypeptide Q8VDR9 UniProt | EBI | MGI Sequence Detail 2080 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 67
      cDNA 64
      Primer pair 2
      Other 1

      Microarray probesets 18
    Other
    Accession IDs
    less
    MGI:1924030, MGI:2442941
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 3
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory