About   Help   FAQ
Ndc80 Gene Detail
Summary
  • Symbol
    Ndc80
  • Name
    NDC80 kinetochore complex component
  • Synonyms
    2610020P18Rik, HEC1, Kntc2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914302
    NCBI Gene: 67052
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:71803095-71833852 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 17, 41.87 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1040 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914302
protein coding gene Chr17:71803095-71833852 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024009
protein coding gene Chr17:73951927-73986512 (-)
A/J MGP_AJ_G0023967
protein coding gene Chr17:71711890-71744947 (-)
AKR/J MGP_AKRJ_G0023936
protein coding gene Chr17:72677620-72707872 (-)
BALB/cJ MGP_BALBcJ_G0023968
protein coding gene Chr17:71607241-71672338 (-)
C3H/HeJ MGP_C3HHeJ_G0023732
protein coding gene Chr17:73636330-73671516 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024414
protein coding gene Chr17:76647869-76685732 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021859
protein coding gene Chr17:67470242-67503995 (-)
CAST/EiJ MGP_CASTEiJ_G0023213
protein coding gene Chr17:74071668-74103968 (-)
CBA/J MGP_CBAJ_G0023707
protein coding gene Chr17:79849522-79884160 (-)
DBA/2J MGP_DBA2J_G0023836
protein coding gene Chr17:70368752-70399988 (-)
FVB/NJ MGP_FVBNJ_G0023802
protein coding gene Chr17:69836555-69875498 (-)
LP/J MGP_LPJ_G0023918
protein coding gene Chr17:74694191-74726455 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023830
protein coding gene Chr17:79691224-79724727 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024458
protein coding gene Chr17:73203688-73235489 (-)
PWK/PhJ MGP_PWKPhJ_G0022959
protein coding gene Chr17:69680357-69711749 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022770
protein coding gene Chr17:69908456-69942611 (-)
WSB/EiJ MGP_WSBEiJ_G0023280
protein coding gene Chr17:74014704-74068950 (-)



Homology
more
  • Human Ortholog
    NDC80, NDC80 kinetochore complex component
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NDC80, NDC80 kinetochore complex component
  • Synonyms
    HEC, HEC1, HsHec1, hsNDC80, KNTC2, TID3
  • Links
    NCBI Gene ID: 10403
    neXtProt AC: NX_O14777
    UniProt: O14777

  • Chr Location
    18p11.32; chr18:2571557-2616635 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show complete embryonic lethality prior to organogenesis. In vitro, blastocysts fail to hatch from the zona pellucida and die after 3 days in culture.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 67052 NCBI Gene Model | MGI Sequence Detail 30758 C57BL/6J ±  kb
transcript NM_023294 RefSeq | MGI Sequence Detail 2201 C57BL/6  
polypeptide Q9D0F1 UniProt | EBI | MGI Sequence Detail 642 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 58
    cDNA 58

    Microarray probesets 3
Other
Accession IDs
less
MGI:3034956
References
more
  • Summaries
    All 49
    Developmental Gene Expression 1
    Gene Ontology 13
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/22/2024
MGI 6.24
The Jackson Laboratory