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Ppp1r2 Gene Detail
Summary
  • Symbol
    Ppp1r2
  • Name
    protein phosphatase 1, regulatory inhibitor subunit 2
  • Synonyms
    0610025N14Rik, 2310007G06Rik, 4930440J04Rik, 5430408E15Rik, I-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914099
    NCBI Gene: 66849
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:31070359-31094095 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 21.41 cM, cytoband B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    129 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914099
 protein coding gene Chr16:31070355-31094095 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022718
 protein coding gene Chr16:29195166-29227313 (-)
A/J MGP_AJ_G0022681
 protein coding gene Chr16:27849716-27877064 (-)
AKR/J MGP_AKRJ_G0022655
 protein coding gene Chr16:28913198-28938005 (-)
BALB/cJ MGP_BALBcJ_G0022685
 protein coding gene Chr16:28032277-28054040 (-)
C3H/HeJ MGP_C3HHeJ_G0022450
 protein coding gene Chr16:29012944-29029961 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023134
 protein coding gene Chr16:29844323-29868825 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020652
 protein coding gene Chr16:28273370-28296816 (-)
CAST/EiJ MGP_CASTEiJ_G0021978
 protein coding gene Chr16:29124369-29148295 (-)
CBA/J MGP_CBAJ_G0022420
 protein coding gene Chr16:31087199-31115129 (-)
DBA/2J MGP_DBA2J_G0022553
 protein coding gene Chr16:27729912-27754033 (-)
FVB/NJ MGP_FVBNJ_G0022528
 protein coding gene Chr16:27700564-27725630 (-)
LP/J MGP_LPJ_G0022620
 protein coding gene Chr16:29016601-29043327 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022547
 protein coding gene Chr16:30574724-30597690 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023146
 protein coding gene Chr16:28857218-28877496 (-)
PWK/PhJ MGP_PWKPhJ_G0021717
 protein coding gene Chr16:28028437-28060960 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021548
 protein coding gene Chr16:28637190-28663658 (-)
WSB/EiJ MGP_WSBEiJ_G0022022
 protein coding gene Chr16:28807567-28827655 (-)



Homology
more
  • Human Ortholog
    PPP1R2, protein phosphatase 1 regulatory inhibitor subunit 2
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP1R2, protein phosphatase 1 regulatory inhibitor subunit 2
  • Synonyms
    IPP2, IPP-2, PPP1R2A
  • Links
    NCBI Gene ID: 5504
    neXtProt AC: NX_P41236
    UniProt: P41236

  • Chr Location
    3q29; chr3:195514428-195543386 (-)  GRCh38
  • Human Ortholog
    PPP1R2B, PPP1R2 family member B
  • Synonyms
    PPP1R2P3
  • Links
    NCBI Gene ID: 153743
    UniProt: Q6NXS1

  • Chr Location
    5q33.3; chr5:156850295-156852528 (+)  GRCh38
  • Human Ortholog
    PPP1R2P1, protein phosphatase 1 regulatory inhibitor subunit 2 pseudogene 1
  • Synonyms
    IPP-2P, PPP1R2P
  • Links
    NCBI Gene ID: 100507444
    UniProt: Q96PQ5

  • Chr Location
    chr6:32876478-32880074 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice die during organogenesis. Heterozygous null mice display responses in behavioral assays suggesting enhanced memory retention.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    9
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    809
  • Tissues
    19
  • cDNA Data
    22
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 66849 NCBI Gene Model | MGI Sequence Detail 23737 C57BL/6J ±  kb
transcript NM_025800 RefSeq | MGI Sequence Detail 4098 ZRU/MplStud  
polypeptide Q9DCL8 UniProt | EBI | MGI Sequence Detail 206 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • PDB
    2O8A, 2O8G
  • InterPro Domains
    IPR007062 Protein phosphatase inhibitor 2 (IPP-2)
Molecular
Reagents
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  • All nucleic 28
    cDNA 26
    Primer pair 2

    Microarray probesets 8
Other
Accession IDs
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MGI:1098743, MGI:1913595, MGI:1918669, MGI:1922115
References
more
  • Summaries
    All 39
    Developmental Gene Expression 6
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:333039 Zhang K, et al., Primary cilia are WNT-transducing organelles whose biogenesis is controlled by a WNT-PP1 axis. Dev Cell. 2023 Jan 23;58(2):139-154.e8
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory