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Stk25 Gene Detail
Summary
  • Symbol
    Stk25
  • Name
    serine/threonine kinase 25 (yeast)
  • Synonyms
    1500019J11Rik, SOK-1, Ste20-like, Ysk1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891699
    NCBI Gene: 59041
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:93548473-93581937 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 47.25 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    93 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891699
 protein coding gene Chr1:93547473-93586381 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016345
 protein coding gene Chr1:95256743-95273183 (-)
A/J MGP_AJ_G0016326
 protein coding gene Chr1:91839732-91883229 (-)
AKR/J MGP_AKRJ_G0016287
 protein coding gene Chr1:94551848-94568773 (-)
BALB/cJ MGP_BALBcJ_G0016282
 protein coding gene Chr1:92022885-92062469 (-)
C3H/HeJ MGP_C3HHeJ_G0016111
 protein coding gene Chr1:94807977-94849779 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016741
 protein coding gene Chr1:98875564-98917547 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014459
 protein coding gene Chr1:86088373-86129286 (-)
CAST/EiJ MGP_CASTEiJ_G0015694
 protein coding gene Chr1:94139940-94185691 (-)
CBA/J MGP_CBAJ_G0016085
 protein coding gene Chr1:102077645-102124730 (-)
DBA/2J MGP_DBA2J_G0016190
 protein coding gene Chr1:91050445-91090738 (-)
FVB/NJ MGP_FVBNJ_G0016189
 protein coding gene Chr1:90110171-90150059 (-)
LP/J MGP_LPJ_G0016261
 protein coding gene Chr1:96433253-96450134 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016214
 protein coding gene Chr1:105171767-105216017 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016780
 protein coding gene Chr1:94571330-94615587 (-)
PWK/PhJ MGP_PWKPhJ_G0015479
 protein coding gene Chr1:90475258-90715458 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015263
 protein coding gene Chr1:93528526-93558772 (-)
WSB/EiJ MGP_WSBEiJ_G0015754
 protein coding gene Chr1:94393731-94435536 (-)



Homology
more
  • Human Ortholog
    STK25, serine/threonine kinase 25
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STK25, serine/threonine kinase 25
  • Synonyms
    SOK1, YSK1
  • Links
    NCBI Gene ID: 10494
    neXtProt AC: NX_O00506
    UniProt: O00506

  • Chr Location
    2q37.3; chr2:241492670-241509730 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Germ line null mutants display normal cortical layers and neuronal migration. Acute loss of expression results in impaired neuronal migration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    876
  • Tissues
    121
  • cDNA Data
    14
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 59041 NCBI Gene Model | MGI Sequence Detail 33465 C57BL/6J ±  kb
transcript NM_021537 RefSeq | MGI Sequence Detail 3254 ZRU/MplStud  
polypeptide Q9Z2W1 UniProt | EBI | MGI Sequence Detail 426 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 15
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1203523, MGI:1916237, MGI:2138417, MGI:2138719
References
more
  • Summaries
    All 61
    Developmental Gene Expression 6
    Gene Ontology 8
    Phenotypes 19
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:334566 Yang X, et al., Release of STK24/25 suppression on MEKK3 signaling in endothelial cells confers cerebral cavernous malformation. JCI Insight. 2023 Mar 8;8(5)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory