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Larp1 Gene Detail
Summary
  • Symbol
    Larp1
  • Name
    La ribonucleoprotein 1, translational regulator
  • Synonyms
    1810024J12Rik, 3110040D16Rik, Larp, mKIAA0731
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890165
    NCBI Gene: 73158
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:57899890-57952860 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 35.55 cM, cytoband B2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    282 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890165
 protein coding gene Chr11:57899711-57952860 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018341
 protein coding gene Chr11:57675434-57730846 (+)
A/J MGP_AJ_G0018311
 protein coding gene Chr11:55490548-55543304 (+)
AKR/J MGP_AKRJ_G0018280
 protein coding gene Chr11:57318103-57376604 (+)
BALB/cJ MGP_BALBcJ_G0018282
 protein coding gene Chr11:55835264-55887831 (+)
C3H/HeJ MGP_C3HHeJ_G0018093
 protein coding gene Chr11:57241264-57297177 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018733
 protein coding gene Chr11:59436141-59494880 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016383
 protein coding gene Chr11:52846088-52899208 (+)
CAST/EiJ MGP_CASTEiJ_G0017658
 protein coding gene Chr11:57326219-57385021 (+)
CBA/J MGP_CBAJ_G0018068
 protein coding gene Chr11:62193364-62249003 (+)
DBA/2J MGP_DBA2J_G0018177
 protein coding gene Chr11:55142194-55195148 (+)
FVB/NJ MGP_FVBNJ_G0018168
 protein coding gene Chr11:54839653-54893673 (+)
LP/J MGP_LPJ_G0018252
 protein coding gene Chr11:58209022-58265397 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018194
 protein coding gene Chr11:63317578-63374410 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018776
 protein coding gene Chr11:57338470-57393620 (+)
PWK/PhJ MGP_PWKPhJ_G0017430
 protein coding gene Chr11:55739781-55794498 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017225
 protein coding gene Chr11:57231613-57291982 (+)
WSB/EiJ MGP_WSBEiJ_G0017705
 protein coding gene Chr11:56989301-57046409 (+)



Homology
more
  • Human Ortholog
    LARP1, La ribonucleoprotein 1, translational regulator
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LARP1, La ribonucleoprotein 1, translational regulator
  • Synonyms
    Lar1, LARP, Lhp1
  • Links
    NCBI Gene ID: 23367
    neXtProt AC: NX_Q6PKG0
    UniProt: Q6PKG0

  • Chr Location
    5q33.2; chr5:154682979-154817605 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    747
  • Tissues
    39
  • cDNA Data
    10
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037331 Ensembl Gene Model | MGI Sequence Detail 52971 C57BL/6J ±  kb
    transcript ENSMUST00000071487 Ensembl | MGI Sequence Detail 6614 Not Applicable  
    polypeptide ENSMUSP00000071421 Ensembl | MGI Sequence Detail 1072 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 10
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1916410, MGI:1920408
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 15
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:300456 Werneck-de-Castro JP, et al., The RNA-binding protein LARP1 is dispensable for pancreatic beta-cell function and mass. Sci Rep. 2021 Jan 22;11(1):2079
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory