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Add3 Gene Detail
Summary
  • Symbol
    Add3
  • Name
    adducin 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351615
    NCBI Gene: 27360
  • Alliance
    genome feature page
  • Transcription Start Sites
    25 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:53128874-53235518 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 47.18 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2840 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351615
 protein coding gene Chr19:53128874-53235830 (+)
129S1/SvImJ ENSMUSG00200020206
 protein coding gene Chr19:49813886-49920755 (+)
A/J ENSMUSG00195016404
 protein coding gene Chr19:49988634-50095518 (+)
AKR/J ENSMUSG00220019167
 protein coding gene Chr19:49758470-49865379 (+)
BALB/cJ ENSMUSG00180015862
 protein coding gene Chr19:50228330-50335207 (+)
C3H/HeJ ENSMUSG00175006211
 protein coding gene Chr19:49763917-49870803 (+)
C57BL/6NJ ENSMUSG00215004491
 protein coding gene Chr19:49856021-49962974 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023069
 protein coding gene Chr19:49642796-49746715 (+)
CAST/EiJ ENSTCUG00005016264
 protein coding gene Chr19:49415462-49522440 (+)
CBA/J ENSMUSG00210018975
 protein coding gene Chr19:49843486-49950389 (+)
DBA/2J ENSMUSG00185008133
 protein coding gene Chr19:50341902-50448791 (+)
FVB/NJ ENSMUSG00205033789
 protein coding gene Chr19:49226736-49333674 (+)
JF1/MsJ ENSUMUG00000043159
 protein coding gene Chr19:50537268-50644505 (+)
LP/J ENSMUSG00230027115
 protein coding gene Chr19:51095617-51202488 (+)
NOD/ShiLtJ ENSMUSG00190005313
 protein coding gene Chr19:49704535-49811384 (+)
NZO/HlLtJ ENSMUSG00225025030
 protein coding gene Chr19:54697893-54804774 (+)
PWK/PhJ ENSLUMG00010000735
 protein coding gene Chr19:49589936-49697071 (+)
SPRET/EiJ ENSMSPG00010007378
 protein coding gene Chr19:49437645-49545480 (+)
WSB/EiJ ENSIUOG00005005768
 protein coding gene Chr19:49197307-49304610 (+)



Homology
more
  • Human Ortholog
    ADD3, adducin 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADD3, adducin 3
  • Synonyms
    ADDL, CPSQ3
  • Links
    NCBI Gene ID: 120
    UniProt: Q9UEY8

  • Chr Location
    10q25.1-q25.2; chr10:109996356-110135565 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ADD3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    9 phenotype references
Mice homozygous for a knock-out allele exhibit normal blood pressure and show no significant alterations in red blood cell or platelet structure and function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    806
  • Tissues
    25
  • cDNA Data
    16
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 27360 NCBI Gene Model | MGI Sequence Detail 106645 C57BL/6J ±  kb
transcript NM_001413986 RefSeq | MGI Sequence Detail 4294 ZRU/MplStud  
polypeptide Q9QYB5 UniProt | EBI | MGI Sequence Detail 706 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    cDNA 16
    Primer pair 3

    Microarray probesets 5
Other
Accession IDs
less
MGI:2147558, MGI:2147811
References
more
  • Summaries
    All 48
    Developmental Gene Expression 5
    Gene Ontology 12
    Phenotypes 9
  • Earliest
    J:33510 Pinto-Correia C, et al., Immunofluorescence localization of an adducin-like protein in the chromosomes of mouse oocytes. Dev Biol. 1991 Aug;146(2):301-11
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory