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Rfc2 Gene Detail
Summary
  • Symbol
    Rfc2
  • Name
    replication factor C (activator 1) 2
  • Synonyms
    2610008M13Rik, 40kDa, 40kDa, Recc2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341868
    NCBI Gene: 19718
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:134611544-134627182 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 74.68 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    99 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341868
 protein coding gene Chr5:134610220-134630659 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030159
 protein coding gene Chr5:138998343-139022153 (+)
A/J MGP_AJ_G0030127
 protein coding gene Chr5:133098120-133120233 (+)
AKR/J MGP_AKRJ_G0030060
 protein coding gene Chr5:137414911-137437418 (+)
BALB/cJ MGP_BALBcJ_G0030137
 protein coding gene Chr5:134439752-134465524 (+)
C3H/HeJ MGP_C3HHeJ_G0029853
 protein coding gene Chr5:137963214-137986969 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030590
 protein coding gene Chr5:144222549-144251886 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027814
 protein coding gene Chr5:127379156-127401609 (+)
CAST/EiJ MGP_CASTEiJ_G0029262
 protein coding gene Chr5:137391825-137415503 (+)
CBA/J MGP_CBAJ_G0029823
 protein coding gene Chr5:149853174-149882144 (+)
DBA/2J MGP_DBA2J_G0029974
 protein coding gene Chr5:132993904-133014504 (+)
FVB/NJ MGP_FVBNJ_G0029929
 protein coding gene Chr5:132126937-132148127 (+)
LP/J MGP_LPJ_G0030062
 protein coding gene Chr5:139478384-139500165 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029961
 protein coding gene Chr5:152918882-152939903 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030630
 protein coding gene Chr5:137139736-137160167 (+)
PWK/PhJ MGP_PWKPhJ_G0028977
 protein coding gene Chr5:132024525-132046056 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028812
 protein coding gene Chr5:134717743-134739890 (+)
WSB/EiJ MGP_WSBEiJ_G0029336
 protein coding gene Chr5:137890440-137914086 (+)



Homology
more
  • Human Ortholog
    RFC2, replication factor C subunit 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RFC2, replication factor C subunit 2
  • Synonyms
    RFC40
  • Links
    NCBI Gene ID: 5982
    neXtProt AC: NX_P35250
    UniProt: P35250

  • Chr Location
    7q11.23; chr7:74231499-74254458 (-)  GRCh38
Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    24
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    133
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 19718 NCBI Gene Model | MGI Sequence Detail 15639 C57BL/6J ±  kb
transcript NM_020022 RefSeq | MGI Sequence Detail 1518 Not Specified  
polypeptide Q9WUK4 UniProt | EBI | MGI Sequence Detail 349 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000013906 replication factor C subunit 2
    (term hierarchy)
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR003959 ATPase, AAA-type, core
    IPR008921 DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR013748 Replication factor C, C-terminal
    IPR047854 Replication factor C, lid domain
Molecular
Reagents
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  • All nucleic 138
    Genomic 3
    cDNA 134
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-13826, MGI:1913827, MGI:2140845, MGI:97892
References
more
  • Summaries
    All 55
    Diseases 2
    Gene Ontology 9
    Phenotypes 18
  • Earliest
    J:40897 Bunz F, et al., cDNAs encoding the large subunit of human replication factor C. Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11014-8
  • Latest
    J:337436 Abdalla N, et al., Dysfunctional Mitochondria in the Cardiac Fibers of a Williams-Beuren Syndrome Mouse Model. Int J Mol Sci. 2023 Jun 13;24(12)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory