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Myh4 Gene Detail
Summary
  • Symbol
    Myh4
  • Name
    myosin, heavy polypeptide 4, skeletal muscle
  • Synonyms
    MHC2B, Minimsc, Minmus, MM, MYH-2B, MyHC-IIb, Myhsf
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339713
    NCBI Gene: 17884
  • Alliance
  • Transcription Start Sites
    61 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:67128855-67151272 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 40.59 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    333 from dbSNP Build 142
  • Strain Annotations
    14
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339713
protein coding gene Chr11:67128638-67151273 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018488
protein coding gene Chr11:67533505-67555896 (+)
A/J MGP_AJ_G0018457
protein coding gene Chr11:65014933-65021971 (+)
AKR/J MGP_AKRJ_G0018426
protein coding gene Chr11:66944207-66968781 (+)
BALB/cJ MGP_BALBcJ_G0018428
protein coding gene Chr11:65278610-65301029 (+)
C3H/HeJ MGP_C3HHeJ_G0018241
protein coding gene Chr11:66956014-66979850 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018880
protein coding gene Chr11:69580151-69606375 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016524
protein coding gene Chr11:61954043-61976962 (+)
CAST/EiJ MGP_CASTEiJ_G0017797
protein coding gene Chr11:67178625-67201078 (+)
CBA/J MGP_CBAJ_G0018215
protein coding gene Chr11:72648011-72676873 (+)
DBA/2J MGP_DBA2J_G0018324
protein coding gene Chr11:64604056-64628426 (+)
FVB/NJ MGP_FVBNJ_G0018314
protein coding gene Chr11:64208342-64232077 (+)
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0018921
protein coding gene Chr11:67184678-67210325 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0017850
protein coding gene Chr11:66793831-66817525 (+)



Homology
more
  • Human Ortholog
    MYH4, myosin heavy chain 4
  • Vertebrate Orthologs
    9
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYH4, myosin heavy chain 4
  • Synonyms
    MYH2B, MyHC-2B, MyHC-IIb
  • Links
    NCBI Gene ID: 4622
    neXtProt AC: NX_Q9Y623
    UniProt: Q9Y623

  • Chr Location
    17p13.1; chr17:10443263-10469559 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit decreased growth and muscle defects including reduced muscle mass, muscle fiber loss, compensatory fiber hypertrophy, and impaired strength.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000057003 Ensembl Gene Model | MGI Sequence Detail 22418 C57BL/6J ±  kb
    transcript ENSMUST00000018632 Ensembl | MGI Sequence Detail 6016 Not Applicable  
    polypeptide ENSMUSP00000018632 Ensembl | MGI Sequence Detail 1939 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      Genomic 9
      cDNA 15
      Primer pair 12
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1261431, MGI:2144213, MGI:4420408
    References
    more
    • Summaries
      All 119
      Developmental Gene Expression 56
      Gene Ontology 6
      Phenotypes 19
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345130 Eguchi T, et al., Calcium-binding protein 7 expressed in muscle negatively regulates age-related degeneration of neuromuscular junctions in mice. iScience. 2024 Feb 16;27(2):108997

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    04/16/2024
    MGI 6.23
    The Jackson Laboratory