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Dyrk1b Gene Detail
Summary
  • Symbol
    Dyrk1b
  • Name
    dual-specificity tyrosine phosphorylation regulated kinase 1b
  • Synonyms
    Mirk
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330302
    NCBI Gene: 13549
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:27878894-27886719 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 16.67 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    141 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330302
 protein coding gene Chr7:27878880-27896896 (+)
129S1/SvImJ ENSMUSG00200040746
 protein coding gene Chr7:17664687-17672512 (+)
A/J ENSMUSG00195048949
 protein coding gene Chr7:20335946-20343771 (+)
AKR/J ENSMUSG00220049946
 protein coding gene Chr7:24140233-24148058 (-)
BALB/cJ ENSMUSG00180049877
 protein coding gene Chr7:18395490-18403315 (+)
C3H/HeJ ENSMUSG00175051587
 protein coding gene Chr7:19438770-19446575 (+)
C57BL/6NJ ENSMUSG00215054185
 protein coding gene Chr7:17568685-17576510 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029435
 protein coding gene Chr7:27394494-27402392 (+)
CAST/EiJ ENSTCUG00005052273
 protein coding gene Chr7:19359650-19367465 (+)
CBA/J ENSMUSG00210051934
 protein coding gene Chr7:18623376-18631181 (+)
DBA/2J ENSMUSG00185045084
 protein coding gene Chr7:21730345-21738170 (+)
FVB/NJ ENSMUSG00205044809
 protein coding gene Chr7:18402952-18410769 (+)
JF1/MsJ ENSUMUG00000049672
 protein coding gene Chr7:26140499-26148314 (+)
LP/J ENSMUSG00230053633
 protein coding gene Chr7:26900897-26908722 (+)
NOD/ShiLtJ ENSMUSG00190051837
 protein coding gene Chr7:18064626-18072451 (+)
NZO/HlLtJ ENSMUSG00225024273
 protein coding gene Chr7:25743989-25751814 (+)
PWK/PhJ ENSLUMG00010042224
 protein coding gene Chr7:18102236-18110051 (+)
SPRET/EiJ ENSMSPG00010037284
 protein coding gene Chr7:17459181-17466944 (+)
WSB/EiJ ENSIUOG00005050471
 protein coding gene Chr7:12331383-12339200 (+)



Homology
more
  • Human Ortholog
    DYRK1B, dual specificity tyrosine phosphorylation regulated kinase 1B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DYRK1B, dual specificity tyrosine phosphorylation regulated kinase 1B
  • Synonyms
    AOMS3, MIRK
  • Links
    NCBI Gene ID: 9149
    UniProt: Q9Y463

  • Chr Location
    19q13.2; chr19:39825350-39834201 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DYRK1B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 3 alleles in 3 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display decreased response of the heart to induced stress.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    605
  • Tissues
    1
  • cDNA Data
    18
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002409 Ensembl Gene Model | MGI Sequence Detail 7826 C57BL/6J ±  kb
    transcript ENSMUST00000172467 Ensembl | MGI Sequence Detail 2523 Not Applicable  
    polypeptide ENSMUSP00000133431 Ensembl | MGI Sequence Detail 689 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000006782 dual specificity tyrosine-phosphorylation-regulated kinase 1B
      (term hierarchy)
    • EC
      2.7.12.1
    • InterPro Domains
      IPR044131 Dual specificity tyrosine-phosphorylation-regulated kinase 1A/1B, catalytic domain
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR050494 Serine/threonine and dual-specificity kinase
      IPR008271 Serine/threonine-protein kinase, active site
    • GlyGen
      Q9Z188 3 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 18

      Microarray probesets 3
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 3
      Gene Ontology 11
      Phenotypes 14
    • Earliest
      J:50326 Becker W, et al., Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. J Biol Chem. 1998 Oct 2;273(40):25893-902
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory