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Ifrd1 Gene Detail
Summary
  • Symbol
    Ifrd1
  • Name
    interferon-related developmental regulator 1
  • Synonyms
    Ifnl, PC4, Tis7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1316717
    NCBI Gene: 15982
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:40253128-40273184 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 18.06 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    612 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1316717
 protein coding gene Chr12:40251566-40298503 (-)
129S1/SvImJ ENSMUSG00200010829
 protein coding gene Chr12:32126337-32147961 (-)
A/J ENSMUSG00195018359
 protein coding gene Chr12:34806416-34828038 (-)
AKR/J ENSMUSG00220004916
 protein coding gene Chr12:32796415-32818037 (-)
BALB/cJ ENSMUSG00180003538
 protein coding gene Chr12:33793568-33815193 (-)
C3H/HeJ ENSMUSG00175016751
 protein coding gene Chr12:36846828-36868449 (-)
C57BL/6NJ ENSMUSG00215010330
 protein coding gene Chr12:33190244-33211867 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017718
 protein coding gene Chr12:36478437-36524802 (-)
CAST/EiJ ENSTCUG00005003606
 protein coding gene Chr12:33558604-33578770 (-)
CBA/J ENSMUSG00210015989
 protein coding gene Chr12:33325921-33347543 (-)
DBA/2J ENSMUSG00185019767
 protein coding gene Chr12:35357168-35378793 (-)
FVB/NJ ENSMUSG00205001392
 protein coding gene Chr12:33207696-33229319 (-)
JF1/MsJ ENSUMUG00000005783
 protein coding gene Chr12:39555080-39575245 (-)
LP/J ENSMUSG00230010132
 protein coding gene Chr12:42291469-42313092 (-)
NOD/ShiLtJ ENSMUSG00190003552
 protein coding gene Chr12:32353480-32375101 (-)
NZO/HlLtJ ENSMUSG00225030793
 protein coding gene Chr12:44510299-44531922 (-)
PWK/PhJ ENSLUMG00010012292
 protein coding gene Chr12:33705748-33725868 (-)
SPRET/EiJ ENSMSPG00010001862
 protein coding gene Chr12:34555564-34577582 (-)
WSB/EiJ ENSIUOG00005001252
 protein coding gene Chr12:33081105-33102731 (-)



Homology
more
  • Human Ortholog
    IFRD1, interferon related developmental regulator 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IFRD1, interferon related developmental regulator 1
  • Synonyms
    PC4, TIS7
  • Links
    NCBI Gene ID: 3475
    UniProt: O00458

  • Chr Location
    7q31.1; chr7:112422887-112481017 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    7 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display impaired muscle regeneration and myogenic differentiation and decreased body weight in older mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    723
  • Tissues
    47
  • cDNA Data
    151
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15982 NCBI Gene Model | MGI Sequence Detail 20057 C57BL/6J ±  kb
    transcript NR_181992 RefSeq | MGI Sequence Detail 1814 ZRU/MplStud  
    polypeptide P19182 UniProt | EBI | MGI Sequence Detail 449 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000008929 interferon-related developmental regulator 1
      (term hierarchy)
    • InterPro Domains
      IPR011989 Armadillo-like helical
      IPR016024 Armadillo-type fold
      IPR039777 Interferon-related developmental regulator
      IPR006921 Interferon-related developmental regulator, C-terminal
      IPR007701 Interferon-related developmental regulator, N-terminal
    • GlyGen
      P19182 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 155
      cDNA 154
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37140, MGI:108103
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 6
      Gene Ontology 7
      Phenotypes 17
    • Earliest
      J:6817 Skup D, et al., Molecular cloning of partial cDNA copies of two distinct mouse IFN-beta mRNAs. Nucleic Acids Res. 1982 May 25;10(10):3069-84
    • Latest
      J:361541 Fashemi BE, et al., IFRD1 is required for maintenance of bladder epithelial homeostasis. iScience. 2024 Dec 20;27(12):111282
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    09/08/2026
    MGI 6.24     		The Jackson Laboratory