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St3gal3 Gene Detail
Summary
  • Symbol
    St3gal3
  • Name
    ST3 beta-galactoside alpha-2,3-sialyltransferase 3
  • Synonyms
    Siat3, Siat6, ST3Gal III
  • Feature Type
    protein coding gene
  • IDs
    MGI:1316659
    NCBI Gene: 20441
  • Alliance
    genome feature page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:117789351-117992111 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 53.84 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6330 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1316659
 protein coding gene Chr4:117789349-117992169 (-)
129S1/SvImJ ENSMUSG00200045986
 protein coding gene Chr4:111688190-111892476 (-)
A/J ENSMUSG00195031941
 protein coding gene Chr4:112940644-113143805 (-)
AKR/J ENSMUSG00220021235
 protein coding gene Chr4:112289715-112497390 (-)
BALB/cJ ENSMUSG00180041239
 protein coding gene Chr4:111007862-111210793 (-)
C3H/HeJ ENSMUSG00175036587
 protein coding gene Chr4:112022088-112225017 (-)
C57BL/6NJ ENSMUSG00215036334
 protein coding gene Chr4:113114207-113317067 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026369
 protein coding gene Chr4:108377784-108582482 (-)
CAST/EiJ ENSTCUG00005020563
 protein coding gene Chr4:111800914-112005272 (-)
CBA/J ENSMUSG00210052684
 protein coding gene Chr4:111635763-111838700 (-)
DBA/2J ENSMUSG00185039486
 protein coding gene Chr4:113166199-113369344 (-)
FVB/NJ ENSMUSG00205018870
 protein coding gene Chr4:111105239-111308152 (-)
JF1/MsJ ENSUMUG00000017041
 protein coding gene Chr4:113084743-113292307 (-)
LP/J ENSMUSG00230041850
 protein coding gene Chr4:116503763-116708026 (-)
NOD/ShiLtJ ENSMUSG00190042346
 protein coding gene Chr4:111003829-111206800 (-)
NZO/HlLtJ ENSMUSG00225010488
 protein coding gene Chr4:121986467-122190740 (-)
PWK/PhJ ENSLUMG00010046171
 protein coding gene Chr4:110467986-110675621 (-)
SPRET/EiJ ENSMSPG00010034288
 protein coding gene Chr4:112566157-112766498 (-)
WSB/EiJ ENSIUOG00005039978
 protein coding gene Chr4:111321674-111524546 (-)



Homology
more
  • Human Ortholog
    ST3GAL3, ST3 beta-galactoside alpha-2,3-sialyltransferase 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ST3GAL3, ST3 beta-galactoside alpha-2,3-sialyltransferase 3
  • Synonyms
    DEE15, EIEE15, MRT12, SIAT6, ST3GALII, ST3Gal III, ST3GalIII, ST3N
  • Links
    NCBI Gene ID: 6487
    UniProt: Q11203

  • Chr Location
    1p34.1; chr1:43705824-43931167 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human ST3GAL3 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    20 phenotype references
Mice homozygous for disruptions in this gene show an apparently normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    748
  • Tissues
    130
  • cDNA Data
    41
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028538 Ensembl Gene Model | MGI Sequence Detail 202761 C57BL/6J ±  kb
transcript ENSMUST00000030263 Ensembl | MGI Sequence Detail 2549 Not Applicable  
polypeptide ENSMUSP00000030263 Ensembl | MGI Sequence Detail 374 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 45
    cDNA 42
    Primer pair 3

    Microarray probesets 4
References
more
  • Summaries
    All 53
    Developmental Gene Expression 5
    Gene Ontology 8
    Phenotypes 20
  • Earliest
    J:41275 Kono M, et al., Mouse beta-galactoside alpha 2,3-sialyltransferases: comparison of in vitro substrate specificities and tissue specific expression. Glycobiology. 1997 Jun;7(4):469-79
  • Latest
    J:334166 Gonzalez-Gil A, et al., Human brain sialoglycan ligand for CD33, a microglial inhibitory Siglec implicated in Alzheimer's disease. J Biol Chem. 2022 Apr 20;298(6):101960
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory