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Kcnj16 Gene Detail
Summary
  • Symbol
    Kcnj16
  • Name
    potassium inwardly-rectifying channel, subfamily J, member 16
  • Synonyms
    6430410F18Rik, Kir5.1
Location &
Maps
more
  • Sequence Map
    Chr11:110858859-110918794 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 75.01 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2225 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1314842
 protein coding gene Chr11:110858859-110918794 (+)
129S1/SvImJ ENSMUSG00200029192
 protein coding gene Chr11:108202852-108263290 (+)
A/J ENSMUSG00195020907
 protein coding gene Chr11:107906761-107967190 (+)
AKR/J ENSMUSG00220029266
 protein coding gene Chr11:108049420-108108325 (+)
BALB/cJ ENSMUSG00180015603
 protein coding gene Chr11:108238729-108297775 (+)
C3H/HeJ ENSMUSG00175012543
 protein coding gene Chr11:108167225-108227674 (+)
C57BL/6NJ ENSMUSG00215005900
 protein coding gene Chr11:107702021-107762485 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017361
 protein coding gene Chr11:106837702-106897435 (+)
CAST/EiJ ENSTCUG00005036990
 protein coding gene Chr11:107618511-107678913 (+)
CBA/J ENSMUSG00210013725
 protein coding gene Chr11:107879780-107940156 (+)
DBA/2J ENSMUSG00185019074
 protein coding gene Chr11:108214800-108275261 (+)
FVB/NJ ENSMUSG00205018764
 protein coding gene Chr11:108050263-108109079 (+)
JF1/MsJ ENSUMUG00000007769
 protein coding gene Chr11:108481196-108541521 (+)
LP/J ENSMUSG00230030585
 protein coding gene Chr11:109275917-109334734 (+)
NOD/ShiLtJ ENSMUSG00190019658
 protein coding gene Chr11:108225562-108284608 (+)
NZO/HlLtJ ENSMUSG00225051248
 protein coding gene Chr11:111321252-111381706 (+)
PWK/PhJ ENSLUMG00010015458
 protein coding gene Chr11:108010052-108070426 (+)
SPRET/EiJ ENSMSPG00010036239
 protein coding gene Chr11:108507036-108566333 (+)
WSB/EiJ ENSIUOG00005017130
 protein coding gene Chr11:107971145-108030110 (+)



Homology
more
  • Human Ortholog
    KCNJ16, potassium inwardly rectifying channel subfamily J member 16
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNJ16, potassium inwardly rectifying channel subfamily J member 16
  • Synonyms
    BIR9, HKTD, KIR5.1
  • Links
    NCBI Gene ID: 3773
    UniProt: Q9NPI9

  • Chr Location
    17q24.3; chr17:70053429-70135608 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal neuron response to ammonium chloride withdrawal and carbon dioxide treatment.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    21
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    632
  • Tissues
    29
  • cDNA Data
    52
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16517 NCBI Gene Model | MGI Sequence Detail 59936 C57BL/6J ±  kb
transcript NM_001252207 RefSeq | MGI Sequence Detail 3704 C57BL/6  
polypeptide Q9Z307 UniProt | EBI | MGI Sequence Detail 419 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000002055 inward rectifier potassium channel 16
    (term hierarchy)
  • InterPro Domains
    IPR014756 Immunoglobulin E-set
    IPR041647 Inward rectifier potassium channel, C-terminal
    IPR016449 Potassium channel, inwardly rectifying, Kir
    IPR008061 Potassium channel, inwardly rectifying, Kir5
    IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
    IPR040445 Potassium channel, inwardly rectifying, transmembrane domain
Molecular
Reagents
less
  • All nucleic 53
    cDNA 52
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2144072, MGI:2442290
References
more
  • Summaries
    All 58
    Developmental Gene Expression 5
    Gene Ontology 10
    Phenotypes 13
  • Earliest
    J:51106 Mouri T, et al., Assignment of mouse inwardly rectifying potassium channel Kcnj16 to the distal region of mouse chromosome 11. Genomics. 1998 Nov 15;54(1):181-2
  • Latest
    J:343328 Xie Z, et al., ZBTB20 is essential for cochlear maturation and hearing in mice. Proc Natl Acad Sci U S A. 2023 Jun 13;120(24):e2220867120
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory