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Nck2 Gene Detail
Summary
  • Symbol
    Nck2
  • Name
    non-catalytic region of tyrosine kinase adaptor protein 2
  • Synonyms
    4833426I10Rik, Grb4, NCKbeta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1306821
    NCBI Gene: 17974
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:43484643-43609678 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 23.18 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1027 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1306821
 protein coding gene Chr1:43483739-43609678 (+)
129S1/SvImJ MGP_129S1SvImJ_G0015980
 protein coding gene Chr1:42446341-42577258 (+)
A/J MGP_AJ_G0015964
 protein coding gene Chr1:41148159-41276171 (+)
AKR/J MGP_AKRJ_G0015919
 protein coding gene Chr1:41709296-41841682 (+)
BALB/cJ MGP_BALBcJ_G0015918
 protein coding gene Chr1:40828135-40955086 (+)
C3H/HeJ MGP_C3HHeJ_G0015751
 protein coding gene Chr1:42082796-42212398 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016371
 protein coding gene Chr1:44175011-44308520 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014093
 protein coding gene Chr1:37975552-38104968 (+)
CAST/EiJ MGP_CASTEiJ_G0015332
 protein coding gene Chr1:42100762-42231401 (+)
CBA/J MGP_CBAJ_G0015723
 protein coding gene Chr1:45468197-45605246 (+)
DBA/2J MGP_DBA2J_G0015824
 protein coding gene Chr1:40430477-40557914 (+)
FVB/NJ MGP_FVBNJ_G0015826
 protein coding gene Chr1:39954162-40082015 (+)
LP/J MGP_LPJ_G0015894
 protein coding gene Chr1:42774413-42903866 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015846
 protein coding gene Chr1:47458857-47588024 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016418
 protein coding gene Chr1:41921174-42050826 (+)
PWK/PhJ MGP_PWKPhJ_G0015115
 protein coding gene Chr1:40316145-40446209 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014897
 protein coding gene Chr1:41924957-42061376 (+)
WSB/EiJ MGP_WSBEiJ_G0015394
 protein coding gene Chr1:41960597-42093195 (+)



Homology
more
  • Human Ortholog
    NCK2, NCK adaptor protein 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NCK2, NCK adaptor protein 2
  • Synonyms
    GRB4, NCKbeta
  • Links
    NCBI Gene ID: 8440
    neXtProt AC: NX_O43639
    UniProt: O43639

  • Chr Location
    2q12.2; chr2:105744453-105894274 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 2 alleles in 1 genetic background
    31 phenotypes from multigenic genotypes
    4 images
    28 phenotype references
Mice homozygous for disruption of this gene display no abnormal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    832
  • Tissues
    72
  • cDNA Data
    10
  • Literature Summary
    7
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 17974 NCBI Gene Model | MGI Sequence Detail 125036 C57BL/6J ±  kb
transcript NM_010879 RefSeq | MGI Sequence Detail 2789 C57BL/6  
polypeptide O55033 UniProt | EBI | MGI Sequence Detail 380 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 10
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:1921842
References
more
  • Summaries
    All 70
    Developmental Gene Expression 7
    Gene Ontology 11
    Phenotypes 28
  • Earliest
    J:39581 Margolis B, et al., High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains. Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):8894-8
  • Latest
    J:327916 Bywaters BC, et al., Endothelial NCK2 promotes atherosclerosis progression in male but not female Nck1-null atheroprone mice. Front Cardiovasc Med. 2022;9:955027
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory