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Egr3 Gene Detail
Summary
  • Symbol
    Egr3
  • Name
    early growth response 3
  • Synonyms
    Pilot
  • Feature Type
    protein coding gene
  • IDs
    MGI:1306780
    NCBI Gene: 13655
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:70314766-70320062 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 36.20 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    13 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1306780
 protein coding gene Chr14:70314652-70320063 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021528
 protein coding gene Chr14:64697561-64700272 (+)
A/J MGP_AJ_G0021487
 protein coding gene Chr14:63340823-63343535 (+)
AKR/J MGP_AKRJ_G0021463
 protein coding gene Chr14:65240573-65243285 (+)
BALB/cJ MGP_BALBcJ_G0021493
 protein coding gene Chr14:63100633-63103345 (+)
C3H/HeJ MGP_C3HHeJ_G0021270
 protein coding gene Chr14:64951660-64954372 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021932
 protein coding gene Chr14:67613921-67616633 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019472
 protein coding gene Chr14:61176569-61179281 (+)
CAST/EiJ MGP_CASTEiJ_G0020787
 protein coding gene Chr14:61534557-61537268 (+)
CBA/J MGP_CBAJ_G0021237
 protein coding gene Chr14:69726596-69729308 (+)
DBA/2J MGP_DBA2J_G0021360
 protein coding gene Chr14:62721975-62724687 (+)
FVB/NJ MGP_FVBNJ_G0021339
 protein coding gene Chr14:62149895-62152607 (+)
LP/J MGP_LPJ_G0021431
 protein coding gene Chr14:65952247-65954958 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021368
 protein coding gene Chr14:68644416-68647128 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021956
 protein coding gene Chr14:64500742-64503454 (+)
PWK/PhJ MGP_PWKPhJ_G0020531
 protein coding gene Chr14:59483115-59485881 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020364
 protein coding gene Chr14:60426325-60429036 (+)
WSB/EiJ MGP_WSBEiJ_G0020840
 protein coding gene Chr14:64806462-64809174 (+)



Homology
more
  • Human Ortholog
    EGR3, early growth response 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EGR3, early growth response 3
  • Synonyms
    EGR-3, PILOT
  • Links
    NCBI Gene ID: 1960
    neXtProt AC: NX_Q06889
    UniProt: Q06889

  • Chr Location
    8p21.3; chr8:22687659-22693480 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 3 alleles in 4 genetic backgrounds
    11 phenotypes from multigenic genotypes
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants exhibit partial postnatal lethality, sensory ataxia, resting tremors, blepharoptosis, scoliosis, muscle spindle agenesis, loss of myelinated proprioceptive neurons, and a defect in the strength of sensory-motor connections.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    817
  • Tissues
    59
  • cDNA Data
    10
  • Literature Summary
    23
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13655 NCBI Gene Model | MGI Sequence Detail 5297 C57BL/6J ±  kb
    transcript NM_001289925 RefSeq | MGI Sequence Detail 4053 C57BL/6  
    polypeptide P43300 UniProt | EBI | MGI Sequence Detail 387 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 1
      cDNA 12
      Primer pair 1
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 110
      Developmental Gene Expression 23
      Gene Ontology 11
      Phenotypes 54
    • Earliest
      J:49519 Patwardhan S, et al., EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors. Oncogene. 1991 Jun;6(6):917-28
    • Latest
      J:346621 Symonds ALJ, et al., Egr2 and 3 maintain anti-tumour responses of exhausted tumour infiltrating CD8 + T cells. Cancer Immunol Immunother. 2023 May;72(5):1139-1151
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory