About   Help   FAQ
Map1b Gene Detail
Summary
  • Symbol
    Map1b
  • Name
    microtubule-associated protein 1B
  • Synonyms
    LC1, MAP5, Mtap1b, Mtap-5, Mtap5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1306778
    NCBI Gene: 17755
  • Alliance
    genome feature page
  • Transcription Start Sites
    81 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:99557954-99653048 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 52.90 cM
  • Mapping Data
    18 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2452 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    2
  • RFLP
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1306778
 protein coding gene Chr13:99557954-99653110 (-)
129S1/SvImJ ENSMUSG00200008399
 protein coding gene Chr13:94137854-94232778 (-)
A/J ENSMUSG00195027447
 protein coding gene Chr13:94606984-94701785 (-)
AKR/J ENSMUSG00220026506
 protein coding gene Chr13:93094567-93189373 (-)
BALB/cJ ENSMUSG00180036035
 protein coding gene Chr13:95141515-95236290 (-)
C3H/HeJ ENSMUSG00175014680
 protein coding gene Chr13:95308363-95403135 (-)
C57BL/6NJ ENSMUSG00215014819
 protein coding gene Chr13:95209452-95304553 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018831
 protein coding gene Chr13:93065293-93159278 (-)
CAST/EiJ ENSTCUG00005011475
 protein coding gene Chr13:94414354-94509549 (-)
CBA/J ENSMUSG00210011388
 protein coding gene Chr13:94641580-94736371 (-)
DBA/2J ENSMUSG00185019028
 protein coding gene Chr13:98302372-98397163 (-)
FVB/NJ ENSMUSG00205031234
 protein coding gene Chr13:94089104-94183894 (-)
JF1/MsJ ENSUMUG00000010898
 protein coding gene Chr13:97971633-98066288 (-)
LP/J ENSMUSG00230035736
 protein coding gene Chr13:108323046-108417965 (-)
NOD/ShiLtJ ENSMUSG00190034510
 protein coding gene Chr13:94971587-95066364 (-)
NZO/HlLtJ ENSMUSG00225033423
 protein coding gene Chr13:100821465-100916221 (-)
PWK/PhJ ENSLUMG00010024488
 protein coding gene Chr13:94071964-94167058 (-)
SPRET/EiJ ENSMSPG00010008958
 protein coding gene Chr13:95414144-95508626 (-)
WSB/EiJ ENSIUOG00005032921
 protein coding gene Chr13:93978827-94073616 (-)



Homology
more
  • Human Ortholog
    MAP1B, microtubule associated protein 1B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAP1B, microtubule associated protein 1B
  • Synonyms
    DFNA83, FUTSCH, MAP5, PPP1R102, PVNH9
  • Links
    NCBI Gene ID: 4131
    UniProt: P46821

  • Chr Location
    5q13.2; chr5:72107234-72209565 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Map1b mouse models; 2 with human MAP1B associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    54 phenotypes from 4 alleles in 6 genetic backgrounds
    12 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one knock-out allele die prior to E8.5. While mice homozygous for other knock-out alleles exhibit behavioral, visual system, and nervous system defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    116
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    916
  • Tissues
    99
  • cDNA Data
    38
  • Literature Summary
    33
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052727 Ensembl Gene Model | MGI Sequence Detail 95095 C57BL/6J ±  kb
    transcript ENSMUST00000064762 Ensembl | MGI Sequence Detail 11808 Not Applicable  
    polypeptide ENSMUSP00000068374 Ensembl | MGI Sequence Detail 2464 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000010117 microtubule-associated protein 1B
      (term hierarchy)
    • InterPro Domains
      IPR026074 Microtubule associated protein 1
      IPR057480 Microtubule-associated protein 1A/B/S-like, MBL-like domain
      IPR056617 Microtubule-associated protein 1B/S, N-terminal domain
      IPR000102 Neuraxin/MAP1B repeat
    • GlyGen
      P14873 9 sites, 1 O-linked glycan (8 sites)
    Molecular
    Reagents
    less
    • All nucleic 58
      Genomic 4
      cDNA 42
      Primer pair 10
      Other 2
      Antibodies 10

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-12583, MGD-MRK-12589, MGI:2145294, MGI:97179
    References
    more
    • Summaries
      All 145
      Developmental Gene Expression 33
      Diseases 1
      Gene Ontology 21
      Phenotypes 37
    • Earliest
      J:34302 Noble M, et al., The microtubule binding domain of microtubule-associated protein MAP1B contains a repeated sequence motif unrelated to that of MAP2 and tau. J Cell Biol. 1989 Dec;109(6 Pt 2):3367-76
    • Latest
      J:387561 Merino F, et al., Nuclear proteome reveals microtubule-associated protein regulating fate and disease. Cell. 2026 Jun 11;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory