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Sorl1 Gene Detail
Summary
  • Symbol
    Sorl1
  • Name
    sortilin-related receptor, LDLR class A repeats-containing
  • Synonyms
    2900010L19Rik, LR11, mSorLA, Sorla
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202296
    NCBI Gene: 20660
  • Alliance
  • Transcription Start Sites
    15 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr9:41876016-42035593 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 9, 23.55 cM, cytoband B
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5216 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202296
protein coding gene Chr9:41876005-42035593 (-)
129S1/SvImJ ENSMUSG00200038770
protein coding gene Chr9:38949282-39109599 (-)
A/J ENSMUSG00195048783
protein coding gene Chr9:38707429-38867629 (-)
AKR/J ENSMUSG00220045920
protein coding gene Chr9:38795036-38957351 (-)
BALB/cJ ENSMUSG00180042946
protein coding gene Chr9:38819153-38979370 (-)
C3H/HeJ ENSMUSG00175044086
protein coding gene Chr9:38831088-38991278 (-)
C57BL/6NJ ENSMUSG00215017962
protein coding gene Chr9:38794213-38953864 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032082
protein coding gene Chr9:38833633-38989547 (-)
CAST/EiJ ENSTCUG00005041657
protein coding gene Chr9:38777650-38940708 (-)
CBA/J ENSMUSG00210039215
protein coding gene Chr9:38876827-39037019 (-)
DBA/2J ENSMUSG00185033387
protein coding gene Chr9:38932758-39095067 (-)
FVB/NJ ENSMUSG00205039809
protein coding gene Chr9:39194016-39354257 (-)
JF1/MsJ ENSUMUG00000044594
protein coding gene Chr9:38984872-39144215 (-)
LP/J ENSMUSG00230033361
protein coding gene Chr9:39240001-39400322 (-)
NOD/ShiLtJ ENSMUSG00190020840
protein coding gene Chr9:39018480-39178664 (-)
NZO/HlLtJ ENSMUSG00225018603
protein coding gene Chr9:39207674-39367998 (-)
PWK/PhJ ENSLUMG00010043908
protein coding gene Chr9:38938256-39098041 (-)
SPRET/EiJ ENSMSPG00010028978
protein coding gene Chr9:39693188-39850038 (-)
WSB/EiJ ENSIUOG00005043572
protein coding gene Chr9:38440605-38600878 (-)



Homology
more
  • Human Ortholog
    SORL1, sortilin related receptor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SORL1, sortilin related receptor 1
  • Synonyms
    C11orf32, gp250, LR11, LRP9, SORLA, SorLA-1
  • Links
    NCBI Gene ID: 6653
    UniProt: Q92673

  • Chr Location
    11q24.1; chr11:121452314-121633763 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human SORL1 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 4 alleles in 5 genetic backgrounds
    5 phenotypes from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in decreased femoral artery intimal thickness after cuff placement and abolished angiotensin II stimulated vascular smooth muscle migration and attachment. Two other alleles show an increase in beta-amyloid deposits or peptide in the brain.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000049313 Ensembl Gene Model | MGI Sequence Detail 159578 C57BL/6J ±  kb
    transcript ENSMUST00000060989 Ensembl | MGI Sequence Detail 10715 Not Applicable  
    polypeptide ENSMUSP00000058613 Ensembl | MGI Sequence Detail 2215 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 2
      cDNA 27
      Primer pair 4
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1920160, MGI:2143102, MGI:2143305
    References
    more
    • Summaries
      All 117
      Developmental Gene Expression 19
      Diseases 1
      Gene Ontology 20
      Phenotypes 40
    • Earliest
      J:46143 Hermans-Borgmeyer I, et al., Unique expression pattern of a novel mosaic receptor in the developing cerebral cortex. Mech Dev. 1998 Jan;70(1-2):65-76
    • Latest
      J:372856 Ma S, et al., SORLA Orchestrates microglial dynamics for enhanced neuroprotection and recovery following ischemic stroke. Brain Behav Immun. 2025 May 17;129:70-86

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    09/08/2026
    MGI 6.24
    The Jackson Laboratory