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Ninj1 Gene Detail
Summary
  • Symbol
    Ninj1
  • Name
    ninjurin 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196617
    NCBI Gene: 18081
  • Alliance
    genome feature page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:49341005-49349727 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 25.14 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    263 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196617
 protein coding gene Chr13:49340961-49349727 (+)
129S1/SvImJ ENSMUSG00200035647
 protein coding gene Chr13:46619762-46628522 (+)
A/J ENSMUSG00195028705
 protein coding gene Chr13:45669391-45678150 (+)
AKR/J ENSMUSG00220009029
 protein coding gene Chr13:45485564-45494330 (+)
BALB/cJ ENSMUSG00180007914
 protein coding gene Chr13:45971654-45980413 (+)
C3H/HeJ ENSMUSG00175027080
 protein coding gene Chr13:45942115-45950874 (+)
C57BL/6NJ ENSMUSG00215005647
 protein coding gene Chr13:46088684-46097442 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018498
 protein coding gene Chr13:44419394-44428607 (+)
CAST/EiJ ENSTCUG00005029058
 protein coding gene Chr13:46001240-46010232 (+)
CBA/J ENSMUSG00210026912
 protein coding gene Chr13:45947493-45956252 (+)
DBA/2J ENSMUSG00185029561
 protein coding gene Chr13:46761502-46770261 (+)
FVB/NJ ENSMUSG00205010207
 protein coding gene Chr13:45730073-45738815 (+)
JF1/MsJ ENSUMUG00000008741
 protein coding gene Chr13:46289021-46298060 (+)
LP/J ENSMUSG00230027896
 protein coding gene Chr13:56082325-56091084 (+)
NOD/ShiLtJ ENSMUSG00190011470
 protein coding gene Chr13:46166381-46175140 (+)
NZO/HlLtJ ENSMUSG00225035767
 protein coding gene Chr13:49832678-49841438 (+)
PWK/PhJ ENSLUMG00010020337
 protein coding gene Chr13:45145481-45154240 (+)
SPRET/EiJ ENSMSPG00010027438
 protein coding gene Chr13:45277308-45284939 (+)
WSB/EiJ ENSIUOG00005027061
 protein coding gene Chr13:45305858-45314630 (+)



Homology
more
  • Human Ortholog
    NINJ1, ninjurin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NINJ1, ninjurin 1
  • Synonyms
    hNINJ1, NIN1, NINJURIN
  • Links
    NCBI Gene ID: 4814
    UniProt: Q92982

  • Chr Location
    9q22.31; chr9:93121496-93134310 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 3 alleles in 3 genetic backgrounds
    2 images
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    7
  • Targeted
    5
  • Genomic Mutations
    1 involving Ninj1
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    18 strains or lines available
Homozygotes for a null allele die prematurely exhibiting hydroencephaly and abnormal cellular replicative senescence. Homozygotes for another null allele show resistance to EAE due to reduced leukocyte recruitment into lesion sites, and may display stunted growth, hydroencephaly, and ataxia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    60
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1046
  • Tissues
    51
  • cDNA Data
    81
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18081 NCBI Gene Model | MGI Sequence Detail 8723 C57BL/6J ±  kb
transcript NM_001436240 RefSeq | MGI Sequence Detail 1318 C57BL/6  
polypeptide O70131 UniProt | EBI | MGI Sequence Detail 152 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 82
    Genomic 1
    cDNA 81

    Microarray probesets 4
Other
Accession IDs
less
MGI:2145366
References
more
  • Summaries
    All 76
    Developmental Gene Expression 4
    Gene Ontology 24
    Phenotypes 28
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:387416 Shao M, et al., Ninjurin-1 Negatively Regulates Humoral and Cellular Immune Responses Induced by the Saponin-Based Adjuvant Quil-A in Mice. Biol Pharm Bull. 2026;49(2):371-379
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory