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Cd180 Gene Detail
Summary
  • Symbol
    Cd180
  • Name
    CD180 antigen
  • Synonyms
    Ly78, RP105
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194924
    NCBI Gene: 17079
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:102830055-102843139 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 54.92 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    131 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1194924
 protein coding gene Chr13:102830055-102876137 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020898
 protein coding gene Chr13:104744500-104796830 (+)
A/J MGP_AJ_G0020849
 protein coding gene Chr13:100661554-100707650 (+)
AKR/J MGP_AKRJ_G0020824
 protein coding gene Chr13:103723783-103771728 (+)
BALB/cJ MGP_BALBcJ_G0020849
 protein coding gene Chr13:101371245-101418250 (+)
C3H/HeJ MGP_C3HHeJ_G0020638
 protein coding gene Chr13:103451875-103509060 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021283
 protein coding gene Chr13:107884682-107935754 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018853
 protein coding gene Chr13:96323974-96369800 (+)
CAST/EiJ MGP_CASTEiJ_G0020157
 protein coding gene Chr13:102916123-102966448 (+)
CBA/J MGP_CBAJ_G0020600
 protein coding gene Chr13:112116920-112172690 (+)
DBA/2J MGP_DBA2J_G0020724
 protein coding gene Chr13:100425095-100472440 (+)
FVB/NJ MGP_FVBNJ_G0020706
 protein coding gene Chr13:99119354-99165785 (+)
LP/J MGP_LPJ_G0020798
 protein coding gene Chr13:104765698-104814244 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020734
 protein coding gene Chr13:112312535-112361908 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021322
 protein coding gene Chr13:103197653-103244029 (+)
PWK/PhJ MGP_PWKPhJ_G0019910
 protein coding gene Chr13:99164298-99211808 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019732
 protein coding gene Chr13:99414137-99462998 (+)
WSB/EiJ MGP_WSBEiJ_G0020215
 protein coding gene Chr13:103660067-103674562 (+)



Homology
more
  • Human Ortholog
    CD180, CD180 molecule
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD180, CD180 molecule
  • Synonyms
    LY64, Ly78, RP105
  • Links
    NCBI Gene ID: 4064
    neXtProt AC: NX_Q99467
    UniProt: Q99467

  • Chr Location
    5q12.3; chr5:67179613-67196799 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    14 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation showed impaired proliferative and humoral immune responses of B cells to lipopolysaccharides.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    9
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 17079 NCBI Gene Model | MGI Sequence Detail 13085 C57BL/6J ±  kb
transcript NM_008533 RefSeq | MGI Sequence Detail 2326 NOD  
polypeptide Q62192 UniProt | EBI | MGI Sequence Detail 661 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 3
References
more
  • Summaries
    All 54
    Gene Ontology 8
    Phenotypes 21
  • Earliest
    J:25726 Miyake K, et al., RP105, a novel B cell surface molecule implicated in B cell activation, is a member of the leucine-rich repeat protein family. J Immunol. 1995 Apr 1;154(7):3333-40
  • Latest
    J:336162 Kani K, et al., The innate immune receptor RP105 promotes metabolic syndrome by altering gut microbiota composition and intestinal barrier function. Biochem Biophys Res Commun. 2023 Jul 5;664:77-85
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory