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Gpc5 Gene Detail
Summary
  • Symbol
    Gpc5
  • Name
    glypican 5
  • Synonyms
    A230034F01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194894
    NCBI Gene: 103978
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:115329647-116762591 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 59.43 cM, cytoband E4
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    43907 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1194894
 protein coding gene Chr14:115329640-116762604 (+)
129S1/SvImJ ENSMUSG00200024394
 protein coding gene Chr14:104226574-105665379 (+)
A/J ENSMUSG00195029659
 protein coding gene Chr14:103981199-105412648 (+)
AKR/J ENSMUSG00220007657
 protein coding gene Chr14:103759168-105199250 (+)
BALB/cJ ENSMUSG00180027795
 protein coding gene Chr14:103473394-104905424 (+)
C3H/HeJ ENSMUSG00175005736
 protein coding gene Chr14:105409163-106841187 (+)
C57BL/6NJ ENSMUSG00215018241
 protein coding gene Chr14:103594890-105027834 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019588
 protein coding gene Chr14:104467326-105820784 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210027074
 protein coding gene Chr14:104377852-105809790 (+)
DBA/2J ENSMUSG00185021153
 protein coding gene Chr14:109534169-110966141 (+)
FVB/NJ ENSMUSG00205006881
 protein coding gene Chr14:103090328-104505218 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230001695
 protein coding gene Chr14:121527970-122959854 (+)
NOD/ShiLtJ ENSMUSG00190023864
 protein coding gene Chr14:104168225-105615526 (+)
NZO/HlLtJ ENSMUSG00225021296
 protein coding gene Chr14:111530692-112949324 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    GPC5, glypican 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPC5, glypican 5
  • Links
    NCBI Gene ID: 2262
    UniProt: P78333

  • Chr Location
    13q31.3; chr13:91398621-92873682 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    5
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    4
  • Transgenic
    1
  • Genomic Mutations
    3 involving Gpc5
  • Incidental Mutations
    Mutagenetix , APF
  • Find Mice (IMSR)
    52 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    701
  • Tissues
    22
  • cDNA Data
    10
  • Literature Summary
    14
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022112 Ensembl Gene Model | MGI Sequence Detail 1432945 C57BL/6J ±  kb
transcript ENSMUST00000176912 Ensembl | MGI Sequence Detail 2837 Not Applicable  
polypeptide ENSMUSP00000135085 Ensembl | MGI Sequence Detail 645 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 10
    Primer pair 4

    Microarray probesets 2
Other
Accession IDs
less
MGI:2442523
References
more
  • Summaries
    All 59
    Developmental Gene Expression 14
    Gene Ontology 5
    Phenotypes 19
  • Earliest
    J:45283 Saunders S, et al., Expression of the cell surface proteoglycan glypican-5 is developmentally regulated in kidney, limb, and brain. Dev Biol. 1997 Oct 1;190(1):78-93
  • Latest
    J:370996 Khouri-Farah N, et al., FOXP genes regulate Purkinje cell diversity and cerebellar morphogenesis. Nat Neurosci. 2025 Aug 18;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory