Evl MGI Mouse Gene Detail - MGI:1194884 - Ena-vasodilator stimulated phosphoprotein

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Evl Gene Detail

Symbol

Evl
Name

Ena-vasodilator stimulated phosphoprotein
Synonyms

b2b2600Clo

Feature Type

protein coding gene
IDs

MGI:1194884
NCBI Gene: 14026
Alliance

gene page
Transcription Start Sites

26 TSS

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Sequence Map

Chr12:108520979-108654775 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 59.46 cM, cytoband F2
Mapping Data

3 experiments

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SNPs within 2kb

1008 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_1194884	protein coding gene	Chr12:108520942-108654775 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020106	protein coding gene	Chr12:110694131-110830095 (+)
A/J	MGP_AJ_G0020060	protein coding gene	Chr12:106489845-106621019 (+)
AKR/J	MGP_AKRJ_G0020036	protein coding gene	Chr12:109580173-109709854 (+)
BALB/cJ	MGP_BALBcJ_G0020046	protein coding gene	Chr12:106900753-107038294 (+)
C3H/HeJ	MGP_C3HHeJ_G0019848	protein coding gene	Chr12:110023774-110155208 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020491	protein coding gene	Chr12:114095754-114235785 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018103	protein coding gene	Chr12:103024009-103148632 (+)
CAST/EiJ	MGP_CASTEiJ_G0019390	protein coding gene	Chr12:104963658-105099654 (+)
CBA/J	MGP_CBAJ_G0019815	protein coding gene	Chr12:118631754-118777939 (+)
DBA/2J	MGP_DBA2J_G0019932	protein coding gene	Chr12:106030741-106161415 (+)
FVB/NJ	MGP_FVBNJ_G0019917	protein coding gene	Chr12:104813318-104942980 (+)
LP/J	MGP_LPJ_G0020007	protein coding gene	Chr12:110562771-110698649 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019955	protein coding gene	Chr12:121815340-121948922 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020520	protein coding gene	Chr12:109062146-109194516 (+)
PWK/PhJ	MGP_PWKPhJ_G0019149	protein coding gene	Chr12:100640957-100772787 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018953	protein coding gene	Chr12:103260298-103395324 (+)
WSB/EiJ	MGP_WSBEiJ_G0019447	protein coding gene	Chr12:109995394-110129109 (+)

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Human Ortholog

EVL, Enah/Vasp-like

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EVL, Enah/Vasp-like
Synonyms

RNB6
Links

HGNC:20234

NCBI Gene ID: 51466

neXtProt AC: NX_Q9UI08

UniProt: Q9UI08
Chr Location

14q32.2; chr14:99971422-100144236 (+) GRCh38

MGI Vertebrate Homology

Evl stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: EVL
Protein SuperFamily

Vasodilator_Phospo
Gene Tree

Evl

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Phenotype Summary

9 phenotypes from 4 alleles in 4 genetic backgrounds
16 phenotypes from multigenic genotypes
9 images
18 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (ENU)

1
Endonuclease-mediated

1
Targeted

8
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

48 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are viable with no apparent defects in gross morphology or histology. Mice homozygous for a different knock-out allele are viable and fertile but display defects in monocyte migration.

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All GO Annotations

29
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

810
Tissues

73
cDNA Data

100
Literature Summary

10

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase evl

ZFIN evla, evlb

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All Sequences

69
RefSeq

14
UniProt

6
CCDS

CCDS26161.1, CCDS49167.1, CCDS49168.1, CCDS49169.1

Ensembl

ENSMUSG00000021262 (Evidence)
NCBI Gene

14026

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000021262	Ensembl Gene Model \| MGI Sequence Detail	133797	C57BL/6J	± kb
	transcript	ENSMUST00000223109	Ensembl \| MGI Sequence Detail	1487	Not Applicable
	polypeptide	ENSMUSP00000152364	Ensembl \| MGI Sequence Detail	426	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000007239 ena/VASP-like protein

(term hierarchy)
PDB

1QC6
InterPro Domains

IPR011993 PH-like domain superfamily

IPR017354 Vasodilator-stimulated phosphoprotein/ENA/VASP-like

IPR014885 VASP tetramerisation

IPR038023 VASP tetramerisation domain superfamily

IPR000697 WH1/EVH1 domain

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All nucleic 101

cDNA 101

Microarray probesets 5

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MGI:2144857, MGI:5560789

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Summaries

All 60

Developmental Gene Expression 10

Gene Ontology 11

Phenotypes 18
Earliest

J:44192 Gertler FB, et al., Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics. Cell. 1996 Oct 18;87(2):227-39
Latest

J:327527 Waldman MM, et al., Ena/VASP Protein-Mediated Actin Polymerization Contributes to Naive CD8(+) T Cell Activation and Expansion by Promoting T Cell-APC Interactions In Vivo. Front Immunol. 2022;13:856977

TSS for Evl:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114983	Chr12:108520929-108520948 (+)	-40 bp
Tssr114984	Chr12:108520960-108520982 (+)	-8 bp
Tssr114985	Chr12:108520993-108521011 (+)	23 bp
Tssr114986	Chr12:108521210-108521239 (+)	246 bp
Tssr114987	Chr12:108572016-108572073 (+)	51,066 bp
Tssr114988	Chr12:108573198-108573202 (+)	52,221 bp
Tssr114989	Chr12:108601963-108601985 (+)	80,995 bp
Tssr114990	Chr12:108602002-108602098 (+)	81,071 bp
Tssr114991	Chr12:108602105-108602117 (+)	81,132 bp
Tssr114992	Chr12:108602495-108602514 (+)	81,526 bp
Tssr114993	Chr12:108614658-108614669 (+)	93,685 bp
Tssr114994	Chr12:108619204-108619234 (+)	98,240 bp
Tssr114996	Chr12:108633448-108633465 (+)	112,478 bp
Tssr114997	Chr12:108633517-108633523 (+)	112,541 bp
Tssr114998	Chr12:108641712-108641751 (+)	120,753 bp
Tssr114999	Chr12:108641758-108641783 (+)	120,792 bp
Tssr115000	Chr12:108642477-108642490 (+)	121,505 bp
Tssr115001	Chr12:108642552-108642555 (+)	121,575 bp
Tssr115002	Chr12:108643448-108643452 (+)	122,471 bp
Tssr115003	Chr12:108643891-108643900 (+)	122,917 bp
Tssr115004	Chr12:108643928-108643933 (+)	122,952 bp
Tssr115005	Chr12:108643986-108643996 (+)	123,012 bp
Tssr115006	Chr12:108644012-108644019 (+)	123,037 bp
Tssr115007	Chr12:108644040-108644056 (+)	123,069 bp
Tssr115008	Chr12:108650906-108650918 (+)	129,933 bp
Tssr115009	Chr12:108654386-108654412 (+)	133,420 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23