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Rnf2 Gene Detail
Summary
  • Symbol
    Rnf2
  • Name
    ring finger protein 2
  • Synonyms
    dinG, Ring1B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1101759
    NCBI Gene: 19821
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:151345159-151376562 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 64.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    868 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1101759
 protein coding gene Chr1:151333755-151376706 (-)
129S1/SvImJ ENSMUSG00200002628
 protein coding gene Chr1:148798597-148807833 (-)
A/J ENSMUSG00195013617
 protein coding gene Chr1:148164651-148173887 (-)
AKR/J ENSMUSG00220005077
 protein coding gene Chr1:147943751-147953119 (-)
BALB/cJ ENSMUSG00180032732
 protein coding gene Chr1:148391229-148400449 (-)
C3H/HeJ ENSMUSG00175002701
 protein coding gene Chr1:148428371-148437607 (-)
C57BL/6NJ ENSMUSG00215003427
 protein coding gene Chr1:148326918-148336139 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014694
 protein coding gene Chr1:142218910-142257192 (-)
CAST/EiJ ENSTCUG00005005617
 protein coding gene Chr1:146940988-146950327 (-)
CBA/J ENSMUSG00210031465
 protein coding gene Chr1:148335234-148344470 (-)
DBA/2J ENSMUSG00185044761
 protein coding gene Chr1:152598560-152607791 (-)
FVB/NJ ENSMUSG00205020576
 protein coding gene Chr1:147469375-147478607 (-)
JF1/MsJ ENSUMUG00000010892
 protein coding gene Chr1:151745589-151754957 (-)
LP/J ENSMUSG00230000246
 protein coding gene Chr1:152121264-152165108 (-)
NOD/ShiLtJ ENSMUSG00190011936
 protein coding gene Chr1:148154654-148163885 (-)
NZO/HlLtJ ENSMUSG00225005077
 protein coding gene Chr1:155840045-155849265 (-)
PWK/PhJ ENSLUMG00010026337
 protein coding gene Chr1:147108725-147118107 (-)
SPRET/EiJ ENSMSPG00010005263
 protein coding gene Chr1:150459151-150467641 (-)
WSB/EiJ ENSIUOG00005022839
 protein coding gene Chr1:147743520-147752891 (-)



Homology
more
  • Human Ortholog
    RNF2, ring finger protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RNF2, ring finger protein 2
  • Synonyms
    BAP-1, BAP1, DING, HIPI3, LUSYAM, RING1B, RING2
  • Links
    NCBI Gene ID: 6045
    UniProt: Q99496

  • Chr Location
    1q25.3; chr1:185044865-185102603 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RNF2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 4 alleles in 6 genetic backgrounds
    24 phenotypes from multigenic genotypes
    63 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a null allele show an early growth arrest, failure to progress through gastrulation, impaired epiblast expansion, accumulation of posterior mesoderm and die before E10.5. Mice homozygous for a hypomorphic allele show posterior homeotic transformations of the axial skeleton.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    92
  • GO References
    40
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    701
  • Tissues
    68
  • cDNA Data
    127
  • Literature Summary
    46
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19821 NCBI Gene Model | MGI Sequence Detail 31404 C57BL/6J ±  kb
    transcript NM_001360844 RefSeq | MGI Sequence Detail 3386 C57BL/6  
    polypeptide Q9CQJ4 UniProt | EBI | MGI Sequence Detail 336 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 130
      cDNA 129
      Primer pair 1
      Antibodies 5

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2138212, MGI:2138251, MGI:2138432
    References
    more
    • Summaries
      All 188
      Developmental Gene Expression 46
      Gene Ontology 40
      Phenotypes 63
    • Earliest
      J:43598 Schoorlemmer J, et al., Ring1A is a transcriptional repressor that interacts with the Polycomb-M33 protein and is expressed at rhombomere boundaries in the mouse hindbrain. EMBO J. 1997 Oct 1;16(19):5930-42
    • Latest
      J:363513 Chen H, et al., The Hao-Fountain syndrome protein USP7 regulates neuronal connectivity in the brain via a novel p53-independent ubiquitin signaling pathway. Cell Rep. 2025 Feb 25;44(2):115231
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    09/08/2026
    MGI 6.24     		The Jackson Laboratory