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Faah Gene Detail
Summary
  • Symbol
    Faah
  • Name
    fatty acid amide hydrolase
  • Feature Type
    protein coding gene
  • IDs
    MGI:109609
    NCBI Gene: 14073
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
  • Candidate for QTL
    5 QTL
Location &
Maps
more
  • Sequence Map
    Chr4:115853865-115876034 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 53.08 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    107 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109609
 protein coding gene Chr4:115824342-115876034 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028614
 protein coding gene Chr4:116811971-116864164 (-)
A/J MGP_AJ_G0028575
 protein coding gene Chr4:112360671-112410798 (-)
AKR/J MGP_AKRJ_G0028524
 protein coding gene Chr4:114763720-114816243 (-)
BALB/cJ MGP_BALBcJ_G0028596
 protein coding gene Chr4:112985412-113035507 (-)
C3H/HeJ MGP_C3HHeJ_G0028310
 protein coding gene Chr4:116344202-116396486 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029037
 protein coding gene Chr4:121339269-121392669 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026321
 protein coding gene Chr4:106404510-106454808 (-)
CAST/EiJ MGP_CASTEiJ_G0027744
 protein coding gene Chr4:113554194-113616150 (-)
CBA/J MGP_CBAJ_G0028277
 protein coding gene Chr4:124640506-124707890 (-)
DBA/2J MGP_DBA2J_G0028425
 protein coding gene Chr4:113005569-113057249 (-)
FVB/NJ MGP_FVBNJ_G0028393
 protein coding gene Chr4:111492958-111545988 (-)
LP/J MGP_LPJ_G0028527
 protein coding gene Chr4:117029159-117082636 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028420
 protein coding gene Chr4:129651698-129709547 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029074
 protein coding gene Chr4:115921987-115977910 (-)
PWK/PhJ MGP_PWKPhJ_G0027470
 protein coding gene Chr4:109767133-109819517 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027293
 protein coding gene Chr4:112167917-112220422 (-)
WSB/EiJ MGP_WSBEiJ_G0027823
 protein coding gene Chr4:115791923-115848143 (-)



Homology
more
  • Human Ortholog
    FAAH, fatty acid amide hydrolase
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FAAH, fatty acid amide hydrolase
  • Synonyms
    FAAH1, FAAH-1, PSAB
  • Links
    NCBI Gene ID: 2166
    neXtProt AC: NX_O00519
    UniProt: O00519

  • Chr Location
    1p33; chr1:46394317-46413848 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human FAAH associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 4 alleles in 5 genetic backgrounds
    3 phenotypes from multigenic genotypes
    84 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show high brain anandamide (AEA) levels, reduced pain sensation, altered behavioral responses to AEA, and sex-specific changes in ethanol intake and sensitivity. Homozygotes for the C385A variant show enhanced cued fear extinction and reduced anxiety-like behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    878
  • Tissues
    29
  • cDNA Data
    72
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14073 NCBI Gene Model | MGI Sequence Detail 22170 C57BL/6J ±  kb
    transcript NR_185205 RefSeq | MGI Sequence Detail 3746 ZRU/MplStud  
    polypeptide O08914 UniProt | EBI | MGI Sequence Detail 579 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 75
      Genomic 1
      cDNA 72
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-39608, MGI:2140571
    References
    more
    • Summaries
      All 128
      Developmental Gene Expression 7
      Gene Ontology 6
      Phenotypes 84
    • Earliest
      J:39332 Giang DK, et al., Molecular characterization of human and mouse fatty acid amide hydrolases. Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2238-42
    • Latest
      J:331785 Simon A, et al., The endocannabinoid anandamide is an airway relaxant in health and disease. Nat Commun. 2022 Nov 17;13(1):6941
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory