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Cntn4 Gene Detail
Summary
  • Symbol
    Cntn4
  • Name
    contactin 4
  • Synonyms
    Axcam, BIG-2A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1095737
    NCBI Gene: 269784
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:105654621-106676271 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 48.93 cM, cytoband E2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    28364 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1095737
 protein coding gene Chr6:105654505-106677102 (+)
129S1/SvImJ ENSMUSG00200024257
 protein coding gene Chr6:102669297-103707348 (+)
A/J ENSMUSG00195016237
 protein coding gene Chr6:102328261-103339340 (+)
AKR/J ENSMUSG00220021866
 protein coding gene Chr6:101257062-102280599 (+)
BALB/cJ ENSMUSG00180002126
 protein coding gene Chr6:102705056-103716039 (+)
C3H/HeJ ENSMUSG00175016278
 protein coding gene Chr6:73694934-74705918 (-)
C57BL/6NJ ENSMUSG00215021414
 protein coding gene Chr6:102723312-103746297 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028696
 protein coding gene Chr6:101236735-102227097 (+)
CAST/EiJ ENSTCUG00005029671
 protein coding gene Chr6:102650366-103666857 (+)
CBA/J ENSMUSG00210020177
 protein coding gene Chr6:102538732-103554525 (+)
DBA/2J ENSMUSG00185018293
 protein coding gene Chr6:103017376-104037583 (+)
FVB/NJ ENSMUSG00205010585
 protein coding gene Chr6:101630780-102637345 (+)
JF1/MsJ ENSUMUG00000001791
 protein coding gene Chr6:101797654-102810897 (+)
LP/J ENSMUSG00230001422
 protein coding gene Chr6:104175258-105213282 (+)
NOD/ShiLtJ ENSMUSG00190016147
 protein coding gene Chr6:102176982-103199920 (+)
NZO/HlLtJ ENSMUSG00225004992
 protein coding gene Chr6:106143711-107154586 (+)
PWK/PhJ ENSLUMG00010015441
 protein coding gene Chr6:101286630-102313270 (+)
SPRET/EiJ ENSMSPG00010014564
 protein coding gene Chr6:103969194-104871951 (+)
WSB/EiJ ENSIUOG00005023151
 protein coding gene Chr6:103064432-104086872 (+)



Homology
more
  • Human Ortholog
    CNTN4, contactin 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CNTN4, contactin 4
  • Synonyms
    AXCAM, BIG-2
  • Links
    NCBI Gene ID: 152330
    UniProt: Q8IWV2

  • Chr Location
    3p26.3-p26.2; chr3:2098813-3057963 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit aberrant projection of olfactory axons to multiple glomeruli in the olfactory bulb.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    634
  • Tissues
    32
  • cDNA Data
    20
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000064293 Ensembl Gene Model | MGI Sequence Detail 1021651 C57BL/6J ±  kb
    transcript ENSMUST00000089208 Ensembl | MGI Sequence Detail 5179 Not Applicable  
    polypeptide ENSMUSP00000086616 Ensembl | MGI Sequence Detail 1026 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 23
      Primer pair 1
      Other 1
      Antibodies 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 13
      Gene Ontology 6
      Phenotypes 19
    • Earliest
      J:41456 Mimmack ML, et al., A novel splice variant of the cell adhesion molecule BIG-2 is expressed in the olfactory and vomeronasal neuroepithelia. Brain Res Mol Brain Res. 1997 Jul;47(1-2):345-50
    • Latest
      J:386463 Rias E, et al., Protocol for isolation of total RNA from mouse whole cochlea using organic solvents. STAR Protoc. 2026 Mar 20;7(1):104376
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory