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Trpc5 Gene Detail
Summary
  • Symbol
    Trpc5
  • Name
    transient receptor potential cation channel, subfamily C, member 5
  • Synonyms
    CCE2, TRP5, Trrp5
Location &
Maps
more
  • Sequence Map
    ChrX:143164667-143471176 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 65.49 cM, cytoband F2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6087 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109524
 protein coding gene ChrX:143160323-143471176 (-)
129S1/SvImJ ENSMUSG00200044572
 protein coding gene ChrX:122179913-122486402 (-)
A/J ENSMUSG00195018539
 protein coding gene ChrX:126011379-126320717 (-)
AKR/J ENSMUSG00220034773
 protein coding gene ChrX:119365337-119671977 (-)
BALB/cJ ENSMUSG00180037448
 protein coding gene ChrX:122433866-122743205 (-)
C3H/HeJ ENSMUSG00175026033
 protein coding gene ChrX:126338782-126645303 (-)
C57BL/6NJ ENSMUSG00215018548
 protein coding gene ChrX:122946106-123252684 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033474
 protein coding gene ChrX:132828427-133113150 (-)
CAST/EiJ ENSTCUG00005032472
 protein coding gene ChrX:123510865-123819100 (-)
CBA/J ENSMUSG00210029474
 protein coding gene ChrX:123262625-123569145 (-)
DBA/2J ENSMUSG00185032734
 protein coding gene ChrX:137153528-137460053 (-)
FVB/NJ ENSMUSG00205024644
 protein coding gene ChrX:121645228-121947555 (-)
JF1/MsJ ENSUMUG00000018883
 protein coding gene ChrX:156383947-156691526 (-)
LP/J ENSMUSG00230031941
 protein coding gene ChrX:143765942-144072425 (-)
NOD/ShiLtJ ENSMUSG00190032905
 protein coding gene ChrX:122639108-122949006 (-)
NZO/HlLtJ ENSMUSG00225041973
 protein coding gene ChrX:148471524-148792432 (-)
PWK/PhJ ENSLUMG00010040264
 protein coding gene ChrX:121098971-121378903 (-)
SPRET/EiJ ENSMSPG00010036399
 protein coding gene ChrX:125840961-126152617 (-)
WSB/EiJ ENSIUOG00005036064
 protein coding gene ChrX:123277981-123594054 (-)



Homology
more
  • Human Ortholog
    TRPC5, transient receptor potential cation channel subfamily C member 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRPC5, transient receptor potential cation channel subfamily C member 5
  • Synonyms
    PPP1R159, TRP5
  • Links
    NCBI Gene ID: 7224
    UniProt: Q9UL62

  • Chr Location
    Xq23; chrX:111768011-112082776 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 4 alleles in 4 genetic backgrounds
    62 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with homozygous null alleles of the gene exhibit diminished innate fear response with reduction in synaptic activation and strength in neurons of the amygdala. Mice homozygous for a null allele exhibit reduced female fertility with reduced prolactin levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    60
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    856
  • Tissues
    105
  • cDNA Data
    13
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041710 Ensembl Gene Model | MGI Sequence Detail 306510 C57BL/6J ±  kb
    transcript ENSMUST00000040184 Ensembl | MGI Sequence Detail 4158 Not Applicable  
    polypeptide ENSMUSP00000049063 Ensembl | MGI Sequence Detail 975 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 1
      cDNA 14
      Primer pair 6

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-39523
    References
    more
    • Summaries
      All 134
      Developmental Gene Expression 12
      Gene Ontology 13
      Phenotypes 62
    • Earliest
      J:33403 Zhu X, et al., trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Cell. 1996 May 31;85(5):661-71
    • Latest
      J:380012 Deng T, et al., A Molecularly Defined Medullary Network for Control of Respiratory Homeostasis. Adv Sci (Weinh). 2025 May;12(18):e2412822
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory